AB25583
Based on 1 publication(s) in Google Scholar
AB25583 is a Polθ helicase (Polθ-hel) small molecule inhibitor, with an IC50 value of 6 nM. AB25583 selectively kills BRCA1/2 deficient cells and works in synergy with Olaparib (HY-10162) in cancer cells carrying pathogenic BRCA1/2 mutations. AB25583 can be used for tumor research.
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- Pureza: 99.87%
- No. CAS: 2565637-94-5
- Fòrmula: C22H17ClN4O3S
- Peso molecular:452.91
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) AB25583
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Actividad biológica
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Helicase |
AB25583 inhibits ATPase activity of Polθ-hel, inhibits microhomology-mediated end joining (MMEJ) expression, hinders the DNA repair process, thereby leading to DNA damage accumulation, especially in cancer cells with BRCA1/2 deficiency[1].
AB25583 (0-10 μM, 24 h) causes the phosphorylation of γH2AX in MDA-MB-436 cell (BRCA1 KO mutant), inhibits the cell survival of MDA-MB-436, reduces the colony density[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-436
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Concentration:0-10 μM
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Incubation Time:24 h
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Result:Promoted the level of phosphorylated γH2AX.
Chemical Information
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No. CAS 2565637-94-5
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Appearance Solid
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Peso molecular 452.91
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Fòrmula C22H17ClN4O3S
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Color White to off-white
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SMILES
ClC1=CC=C(COC2=NN=C(NC(C3=C(C4=CC=CC=C4OC)C=CN=C3)=O)S2)C=C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
Solvente y solubilidad
DMSO : 125 mg/mL (275.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2079 mL | 11.0397 mL | 22.0794 mL | 55.1986 mL |
| 5 mM | 0.4416 mL | 2.2079 mL | 4.4159 mL | 11.0397 mL | |
| 10 mM | 0.2208 mL | 1.1040 mL | 2.2079 mL | 5.5199 mL | |
| 15 mM | 0.1472 mL | 0.7360 mL | 1.4720 mL | 3.6799 mL | |
| 20 mM | 0.1104 mL | 0.5520 mL | 1.1040 mL | 2.7599 mL | |
| 25 mM | 0.0883 mL | 0.4416 mL | 0.8832 mL | 2.2079 mL | |
| 30 mM | 0.0736 mL | 0.3680 mL | 0.7360 mL | 1.8400 mL | |
| 40 mM | 0.0552 mL | 0.2760 mL | 0.5520 mL | 1.3800 mL | |
| 50 mM | 0.0442 mL | 0.2208 mL | 0.4416 mL | 1.1040 mL | |
| 60 mM | 0.0368 mL | 0.1840 mL | 0.3680 mL | 0.9200 mL | |
| 80 mM | 0.0276 mL | 0.1380 mL | 0.2760 mL | 0.6900 mL | |
| 100 mM | 0.0221 mL | 0.1104 mL | 0.2208 mL | 0.5520 mL |
AB25583 Related Classifications
HY-162859 Related Classifications
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