country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Referencia número: HY-N14664

Copy Link Print Information

Actithiazic acid

(Synonyms: Mycobacidin; Cinnamonin; Acidomycin)

Actithiazic acid is a thiazolidinone antibiotic that targets biotin synthase. Actithiazic acid interferes with essential bacterial metabolism by inhibiting the final step of biotin synthesis (conversion of desthiobiotin to biotin, IC₅₀ = 0.45 μM). Actithiazic acid can be used in studies related to mycobacterial infections.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 539-35-5
Fòrmula: C₉H₁₅NO₃S
Peso molecular:217.29

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

Actithiazic acid Chemical Structure

No. CAS: 539-35-5

Tamaño

Precio

Stock

Cantidad

Amount: USD 0.00

* Seleccione Cantidad antes de agregar artículos.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

Ver todos los productos específicos de isoformas Antibiotic :

In Vitro

Actithiazic acid (0.45-3.9 μM; 20 min) inhibits the enzymatic conversion of desthiobiotin to biotin in resting cell suspensions of Escherichia coli K-12 strain ABD313-136, with an IC₅₀ of 0.45 μM^[1].
Actithiazic acid (1 μg/mL) induces derepression of the biotin A operon in Escherichia coli K-12 strain Y10-1, with the maximum enhancement of 7,8-diaminopelargonic acid aminotransferase and desthiobiotin synthetase activities observed at the concentration of 1 μg/mL^[1].
Actithiazic acid promotes the excretion of biotin-like substances in growth cultures of Escherichia coli and various other microorganisms^[1].
Combination of actithiazic acid (10-50 μg/mL; 18 h) with Cephalexin (HY-B0200) exerts moderate synergistic effects against *Escherichia coli* 9632 in nutrient broth^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 539-35-5
Peso molecular 217.29
Fòrmula C₉H₁₅NO₃S
SMILES

O=C(CCCCCC1SCC(N1)=O)O
Synonyms

Mycobacidin; Cinnamonin; Acidomycin
Structure Classification
- Antibiotics
- Other Antibiotics
Initial Source
- Microorganisms
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Eisenberg MA, et al. Mode of action of the biotin antimetabolites actithiazic acid and alpha-methyldethiobiotin. Antimicrob Agents Chemother. 1982;21(1):5-10. [Content Brief]

[2]. Nadkarni SR, et al. In vitro synergy of actithiazic acid, an antimetabolite of biotin, combined with cephalexin. The Journal of Antibiotics. 1983;36(11):1567-8.

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

MOQ

Minimum order quantity

100 mg

Obtener un presupuesto En stock

Other size

Obtener un presupuesto

Amount: USD 0.00

Actividad biológica
- Descripciòn
- In Vitro
Chemical Information
Pureza y Documentación
Referencias

Nombre del producto:
Referencia número:
Cantidad:
MCE Japan Authorized Agent:

Nombre del producto:
No. CAS:
Species:
Pureza:
Cantidad:

Actithiazic acid

Ver todos los productos específicos de isoformas Antibiotic

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

Actithiazic acid Related Classifications

HY-N14664 Related Classifications