Anticancer agent 345
Anticancer agent 345 is a heterobifunctional anticancer compound that exhibits weak antiproliferative activity against both ERα-overexpressing and non-overexpressing T-Rex 293 cells. Anticancer agent 345 can be used in cancer-related research.
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- No. CAS: 3099598-25-8
- Fòrmula: C54H57N7O3S
- Peso molecular:884.14
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
- Protocolo
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Descripciòn
IC50 & Target
[1]|
ERα |
In Vitro
Anticancer agent 345 (III-154) exhibits moderate antiproliferative activity against MCF7 cells (GI50 = 0.0-0.5 μM)[1].
Anticancer agent 345 exhibits weak antiproliferative activity against both estrogen receptor α-overexpressing and non-overexpressing T-Rex 293 cells induced by Doxorubicin (HY-15142A) (GI50 > 2.5 μM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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No. CAS 3099598-25-8
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Peso molecular 884.14
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Fòrmula C54H57N7O3S
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SMILES
CC1=C(C)SC2=C1C(C3=CC=C(N4CCC(O)(CC4)CC5CCN(C6=CC=C([C@@H]7C8=CC=C(O)C=C8CC[C@@H]7C9=CC=CC=C9)C=C6)CC5)C=C3)=N[C@H](CC%10=NC=CO%10)C%11=NN=C(C)N2%11
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocolo
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Cell Viability Determination by MTT Colorimetric Assay
The following protocol uses the MTT colorimetric assay as a classic literature-established method for assessing cell viability/metabolic activity in cultured mammalian cells. MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] is reduced by metabolically active cells to a colored formazan product; the amount of formazan is quantified spectrophotometrically and provides an indirect measure of metabolically active viable cells. Importantly, MTT reduction reflects cellular oxidoreductase/metabolic activity rather than an absolute direct count of living cells, so changes in cellular metabolism can alter the signal independently of cell number.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anticancer agent 345 Related Classifications
HY-184953 Related Classifications
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