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Referencia número: HY-150571

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Anticancer agent 76

Anticancer agent 76 (Compound CT2-3) is an anticancer agent. Anticancer agent 76 significantly inhibits the proliferation of human NSCLC cells, induces cell cycle arrest, causes ROS generation and induces cell apoptosis.

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No. CAS: 2448091-11-8
Fòrmula: C₃₂H₃₃NO₅S
Peso molecular:543.67

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Anticancer agent 76 Chemical Structure

No. CAS: 2448091-11-8

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Actividad biológica
- Descripciòn
- Cellular Effect
- In Vitro
Chemical Information
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Actividad biológica

Descripciòn

Ver todos los productos específicos de isoformas Topoisomerase :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	41.63 μM Compound: CT2-3	Antiproliferative activity against human A549 cells assessed as inhibition of cell viability incubated for 24 hrs by CCK-8 assay Antiproliferative activity against human A549 cells assessed as inhibition of cell viability incubated for 24 hrs by CCK-8 assay	[PMID: 32044229]
NCI-H460	IC₅₀	38.03 μM Compound: CT2-3	Antiproliferative activity against human H460 cells assessed as inhibition of cell viability incubated for 24 hrs by CCK-8 assay Antiproliferative activity against human H460 cells assessed as inhibition of cell viability incubated for 24 hrs by CCK-8 assay	[PMID: 32044229]

In Vitro

Anticancer agent 76 (Compound CT2-3) (0-80 μM, 24 h) inhibits the proliferation of human NSCLC cells^[1].
Anticancer agent 76 (40 μM, 24 h) arrests cell cycle at G1 phase, induces apoptosis and ROS, suppresses the expression of c-Myc and topoisomerases in NSCLC cells ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

A549 and H460
Concentration:

0, 10, 20, 40, 60 and 80 μM
Incubation Time:

24 h
Result:

Inhibited the proliferation with IC₅₀ values of 41.63 μM and 38.03 μM against A549 and H460 cells, respectively.

Cell Cycle Analysis^[1]

Cell Line:

H460
Concentration:

40 μM
Incubation Time:

24 h
Result:

Resulted in increasing cell populations at the G1 phase, down-regulated CDK4, CDK6 and cyclin D1.

Apoptosis Analysis^[1]

Cell Line:

A549 and H460
Concentration:

20 μM and 40 μM
Incubation Time:

24 h
Result:

Induced apoptosis.

Western Blot Analysis^[1]

Cell Line:

H460 cell
Concentration:

40 μM
Incubation Time:

24 h
Result:

Down-regulated mRNA of TOP2B, TOP3B and c-Myc.

Chemical Information

No. CAS 2448091-11-8
Peso molecular 543.67
Fòrmula C₃₂H₃₃NO₅S
SMILES

O=C1N(CCCCS(CCOC2=CC=C(CC=C)C=C2C3=CC(CC=C)=CC=C3O)=O)C(C4=C1C=CC=C4)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Chen J, et al. CT2-3, a novel magnolol analogue suppresses NSCLC cells through triggering cell cycle arrest and apoptosis. Bioorg Med Chem. 2020 Mar 15;28(6):115352. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Anticancer agent 76

Ver todos los productos específicos de isoformas Topoisomerase