AS2-10
AS2-10 is a cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 3.6 μM. AS2-10 inhibits COX-2 through hydrogen bonding and electrostatic interactions within the catalytic pocket, and also exhibits inhibitory activity against COX-1. AS2-10 possesses peripheral analgesic and anti-inflammatory effects, alleviating acetic acid-induced writhing, formalin-induced licking responses, and Carrageenan (HY-125474)-induced paw edema. AS2-10 can be used in research related to inflammation and pain.
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- Fòrmula: C25H22FNO3
- Peso molecular:403.45
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Actividad biológica
Descripciòn
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Murine 3T3 fibroblast cells
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Concentration:30 μg/mL
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Incubation Time:24-48 h
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Result:Produced 8.74% inhibition of cell viability.
In Vivo
AS2-10 (10 mg/kg; i.p.) significantly attenuates both neurogenic (phase I) and inflammatory (phase II) pain responses in the formalin-induced paw licking test[1].
AS2-10 (10 mg/kg; i.p.) significantly inhibits Carrageenan (HY-125474) -induced paw edema in mice, demonstrating notable anti-inflammatory efficacy[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Albino mice (adult, male and female, 6-7 weeks, 25-30 g)[1]
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Dosage:10 mg/kg
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Administration:i.p.; single dose
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Result:Reduced the average number of writhing responses to 22.
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Animal Model:Albino mice (adult, male and female, 6-7 weeks, 25-30 g)[1]
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Dosage:10 mg/kg
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Administration:i.p..; single dose
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Result:Reduced phase I paw licking/biting time to 23.0 seconds.
Reduced phase II paw licking/biting time to 114.6 seconds.
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Animal Model:Albino mice (adult, male and female, 6-7 weeks, 25-30 g)[1]
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Dosage:10 mg/kg
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Administration:i.p..; single dose
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Result:Demonstrated a paw thickness of 4.13 mm at 5 h.
Chemical Information
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Peso molecular 403.45
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Fòrmula C25H22FNO3
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SMILES
O=C(NCC1=CC=C(F)C=C1)COC2=CC=C(C(/C=C/C3=CC=C(C)C=C3)=O)C=C2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AS2-10 Related Classifications
HY-189394 Related Classifications
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