BLT-1
Based on 13 publication(s) in Google Scholar
BLT-1, a thiosemicarbazone copper chelator, is a selective scavenger receptor B, type 1 (SR-BI) inhibitor. BLT-1 inhibits the transfer of lipids between high-density lipoproteins (HDL) and cells mediated by SR-BI. BLT-1 is a potent HCV entry inhibitor.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.93%
- No. CAS: 321673-30-7
- Fòrmula: C12H23N3S
- Peso molecular:241.40
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Anti-Infection Compound Library
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Publications Citing Use of MedChemExpress (MCE) BLT-1
More- Cancer Discov. 2023 Feb 6;13(2):454-473. [Abstract]
- Cancer Res. 2025 Aug 1;85(15):2805-2819. [Abstract]
- Nat Commun. 2026 Mar 11;17(1):3794. [Abstract]
- Adv Sci (Weinh). 2026 Apr;13(23):e15742. [Abstract]
- Cardiovasc Res. 2025 Nov 21:cvaf254. [Abstract]
- Cell Death Dis. 2025 Dec 13. [Abstract]
- Mol Ther. 2025 Dec 3;33(12):6518-6536. [Abstract]
- Food Res Int. 2026 Mar 31:228:118352. [Abstract]
- Cell Rep. 2025 Jun 6;44(6):115792. [Abstract]
- Nutrients. 2026 Jan;18(9):1389.
- iScience. 2024 Feb 6;27(3):109119. [Abstract]
- FEBS J. 2022 May;289(10):2809-2827. [Abstract]
- bioRxiv. 2026 Jun 1.
Customer Validation & Images
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Cell Imaging/Staining
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Cell Imaging/Staining
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In Vivo Efficacy Study
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IHC
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Cell Proliferation/Viability Assay
Actividad biológica
BLT-1 has IC50s of 60 and 110 nM for cellular DiI-HDL and [3H]CE-HDL uptake in ldlA[mSR-BI] cells[1].
BLT-1 has an IC50 of 0.96 μM for the HCV entry in Huh 7.5.1 cells[4].
BLT-1 (50 μM; 3 hours) does not induce general defects in clathrin-dependent and -independent intracellular membrane trafficking in HeLa, BSC-1 cells[1].
BLT-1 can inhibit SR-BI-dependent selective uptake of [3H]CE from [3H]CE-HDL by mSR-BI-t1-containing liposomes in cells (IC50=0.057 μM) and liposomes (IC50=0.098 μM) [2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 321673-30-7
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Appearance Solid
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Peso molecular 241.40
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Fòrmula C12H23N3S
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Color White to light yellow
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SMILES
CCCCCCC1CCC/C1=N/NC(N)=S
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Synonyms
Block lipid transport-1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (13)
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Journal Impact Factor
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Most Recent
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Cancer Discov
2023 Feb 6;13(2):454-473. PMID: 36331284
BLT-1 purchased from MedChemExpress. Usage Cited in: Cancer Discov. 2023 Feb 6;13(2):454-473. [Abstract]
Inhibition of the SR-B1 using the selective chemical inhibitor BLT-1 (5 µM) results in a modestly enhance DC661 cytotoxicity.
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Cancer Res
Pancreatic Neuroendocrine Tumors Secrete Apolipoprotein E to Induce Tip Endothelial Cells That Remodel the Tumor-Stroma Ratio and Promote Cancer Progression. [Abstract]2025 Aug 1;85(15):2805-2819. PMID: 40623046 -
Nat Commun
A hierarchical theranostic nanoagent for multimodal imaging and targeted foam cell intervention in atherosclerosis. [Abstract]2026 Mar 11;17(1):3794. PMID: 41807467 -
Adv Sci (Weinh)
SR-B1-Mediated Transplacental Transfer of Hydrophobic Toxicants Disrupts Fetal Development During Barriergenesis. [Abstract]2026 Apr;13(23):e15742. PMID: 41736660 -
Cardiovasc Res
Loss of GPR146 decreases plasma levels of HDL cholesterol via post-translational upregulation of SR-B1 protein levels. [Abstract]2025 Nov 21:cvaf254. PMID: 41271608 -
Cell Death Dis
Tumor-derived apolipoprotein E confers resistance to temozolomide in pancreatic neuroendocrine tumors. [Abstract]2025 Dec 13. PMID: 41390817 -
Mol Ther
α-Tocopherol ameliorates allergic airway inflammation by regulating ILC2 ferroptosis in an LKB1-dependent manner. [Abstract]2025 Dec 3;33(12):6518-6536. PMID: 40898617
BLT-1 purchased from MedChemExpress. Usage Cited in: Mol Ther. 2025 Dec 3;33(12):6518-6536. [Abstract]
BLT-1 (100 nM). Confocal laser scanning microscopy and quantification also revealed an increased proportion of γH2AX foci in PDCs after 48 h treatment. Scale bar, 10 μm.
BLT-1 purchased from MedChemExpress. Usage Cited in: Mol Ther. 2025 Dec 3;33(12):6518-6536. [Abstract]
Both TMZ treatment alone and BLT-1 (100 nM) + TMZ cotreatment effectively reduced the growth of PDOs after 72 h treatment. Confocal images β-catenin in organoid co-treated with TMZ and BLT-1 and quantification of the mean intensity. Scale bar, 50 μm.
BLT-1 purchased from MedChemExpress. Usage Cited in: Mol Ther. 2025 Dec 3;33(12):6518-6536. [Abstract]
Effect of TMZ treatment alone and BLT-1 (50 mg/kg/day, oral gavage for 3 weeks) + TMZ in PDX. Tumor weight, Tumor growth curves, and Representative graphs of tumors.
BLT-1 purchased from MedChemExpress. Usage Cited in: Mol Ther. 2025 Dec 3;33(12):6518-6536. [Abstract]
IHC staining of PDX showed that the higher expression of β-catenin, and BRCA1/2 induced by TMZ was reversed by BLT-1 (50 mg/kg/day, oral gavage for 3 weeks) + TMZ. Scale bar, 50 μm.
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Food Res Int
Hydroxypropyl-β-cyclodextrin as a co-delivery vehicle for synergistically enhancing fucoxanthin oral bioavailability through dual regulation of SR-B1 and ABCB1 transporters. [Abstract]2026 Mar 31:228:118352. PMID: 41703824 -
Cell Rep
Cholesterol metabolism regulated by CAMKK2-CREB signaling promotes castration-resistant prostate cancer. [Abstract]2025 Jun 6;44(6):115792. PMID: 40483692 -
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iScience
Dendritic cells overcome Cre/Lox induced gene deficiency by siphoning cytosolic material from surrounding cells. [Abstract]2024 Feb 6;27(3):109119. PMID: 38384841 -
FEBS J
TNF-α/ENO1 signaling facilitates testicular phagocytosis by directly activating Elmo1 gene expression in mouse Sertoli cells. [Abstract]2022 May;289(10):2809-2827. PMID: 34919331 -
Solvente y solubilidad
DMSO : 41.67 mg/mL (172.62 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (8.62 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.08 mg/mL (8.62 mM); Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 2.08 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Nieland TJ, et al. Discovery of chemical inhibitors of the selective transfer of lipids mediated by the HDL receptorSR-BI. Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15422-7. [Content Brief]
[2]. Nieland TJ, et al. Identification of the molecular target of small molecule inhibitors of HDL receptor SR-BI activity. Biochemistry. 2008 Jan 8;47(1):460-72. [Content Brief]
[3]. Raldúa D, et al. BLT-1, a specific inhibitor of the HDL receptor SR-BI, induces a copper-dependent phenotype during zebrafish development. Toxicol Lett. 2007 Dec 10;175(1-3):1-7. Epub 2007 Aug 22. [Content Brief]
[4]. Hirofumi Ohashi, et al. Reply to Padmanabhan and Dixit: Hepatitis C virus entry inhibitors for optimally boosting direct-acting antiviral-based treatments. Proc Natl Acad Sci U S A. 2017 Jun 6;114(23):E4527-E4529. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.1425 mL | 20.7125 mL | 41.4250 mL | 103.5626 mL |
| 5 mM | 0.8285 mL | 4.1425 mL | 8.2850 mL | 20.7125 mL | |
| 10 mM | 0.4143 mL | 2.0713 mL | 4.1425 mL | 10.3563 mL | |
| 15 mM | 0.2762 mL | 1.3808 mL | 2.7617 mL | 6.9042 mL | |
| 20 mM | 0.2071 mL | 1.0356 mL | 2.0713 mL | 5.1781 mL | |
| 25 mM | 0.1657 mL | 0.8285 mL | 1.6570 mL | 4.1425 mL | |
| 30 mM | 0.1381 mL | 0.6904 mL | 1.3808 mL | 3.4521 mL | |
| 40 mM | 0.1036 mL | 0.5178 mL | 1.0356 mL | 2.5891 mL | |
| 50 mM | 0.0829 mL | 0.4143 mL | 0.8285 mL | 2.0713 mL | |
| 60 mM | 0.0690 mL | 0.3452 mL | 0.6904 mL | 1.7260 mL | |
| 80 mM | 0.0518 mL | 0.2589 mL | 0.5178 mL | 1.2945 mL | |
| 100 mM | 0.0414 mL | 0.2071 mL | 0.4143 mL | 1.0356 mL |
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