BMP-4 (15-24)
Based on 1 publication(s) in Google Scholar
BMP-4 (15-24) is a cell-penetrating heparin-binding peptide with the sequence RKKNPNCRRH. BMP-4 (15-24) exhibits anti-inflammatory and anti-chondrogenic activities. BMP-4 (15-24) can be used in the research of arthritis.
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- No. CAS: 1629625-47-3
- Fòrmula: C52H93N25O13S
- Peso molecular:1308.52
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Publications Citing Use of MedChemExpress (MCE) BMP-4 (15-24)
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Actividad biológica
Descripciòn
IC50 & Target
[2]|
IL-6 |
COX-2 |
In Vitro
BMP-4 (15-24) (0-100 μg/mL; 24 h) inhibits the expression of inflammatory proteins including iNOS, COX2, IFNγ, and IL-6 in LPS (HY-D1056)-stimulated RAW264.7 macrophages[2].
BMP-4 (15-24) (0-100 μg/mL) dose-dependently upregulates the mRNA expression of cartilage marker genes AGG, COLII, and TNFα in human articular chondrocytes NHAC[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:LPS treated RAW264.7
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Concentration:0, 10, 50, 100 μg/mL
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Incubation Time:24 h
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Result:Inhibited the levels of iNOS, COX-2, IFNγ and IL6 in a dose-dependent manner.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:DBA/1 mice (male, 21-24 g, 7 weeks old) with collagen-induced arthritis (CIA)[2]
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Dosage:30 mg/kg
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Administration:subcutaneous injection; twice weekly for 4 consecutive weeks
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Result:Significantly reduced the arthritis score and hind paw swelling degree, and inhibits the serum concentrations of proinflammatory cytokines IFNγ and IL-6.
Alleviated synovial hyperplasia, pannus formation and bone erosion, and repairs the damage of glycosaminoglycan (GAG) area in articular cartilage.
Chemical Information
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No. CAS 1629625-47-3
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Peso molecular 1308.52
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Fòrmula C52H93N25O13S
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Sequence
Arg-Lys-Lys-Asn-Pro-Asn-Cys-Arg-Arg-His
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Sequence Shortening
RKKNPNCRRH
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Mater Today Bio
Synergistic 3D-bioprinted scaffold with multi-level adaptability for vascularized bone regeneration via osteogenesis-angiogenesis coupling. [Abstract]2026 Jan 21:37:102837. PMID: 41660131
Pureza y Documentación
Referencias
[1]. Pathade V, et al. Emerging insights of peptide-based nanotherapeutics for effective management of rheumatoid arthritis. Life Sci. 2023;312:121257. [Content Brief]
[2]. Choi DH, et al. A Synthetic Cell-Penetrating Heparin-Binding Peptide Derived from BMP4 with Anti-Inflammatory and Chondrogenic Functions for the Treatment of Arthritis. Int J Mol Sci. 2020;21(12):4251. Published 2020 Jun 15. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BMP-4 (15-24) Related Classifications
HY-P10710 Related Classifications
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