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Referencia número: HY-P11646

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Brazzein

Name: Brazzein
Brand: MedChemExpress
SKU: HY-P11646
Availability: PreOrder

Brazzein is a functional sweetener with antioxidant, anti-inflammatory, and anti-allergic activities.

Brazzein inhibits COX-2 with an IC₅₀ of 12.62 μM. Brazzein exhibits strong antioxidant effects, showing ABTS radical scavenging activity (IC₅₀ = 12.55 μM). Brazzein shows no antibacterial or antifungal activity. Brazzein can be used for the research of obesity, metabolic disorder, inflammation.

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No. CAS: 178359-31-4
Fòrmula: C₂₇₆H₄₁₀N₇₆O₈₉S₈
Peso molecular:6473.18

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Brazzein Chemical Structure

No. CAS: 178359-31-4

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Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

Brazzein is a functional sweetener with antioxidant, anti-inflammatory, and anti-allergic activities.

IC₅₀ & Target^[1]

COX-2

12.62 μM (IC₅₀)

Ver todos los productos específicos de isoformas COX :

In Vitro

Brazzein (15-30 μM) shows strong ABTS radical scavenging activity with an IC₅₀ of 12.55 μM in cell-free conditions^[1].
Brazzein (15-30 μM; 30 min) shows weaker DPPH radical scavenging activity compared to ABTS, with an IC₅₀ > 30 μM in cell-free conditions^[1].
Brazzein (3-25 μM) inhibits human COX-2 activity with an IC₅₀ of 12.62 μM in cell-free conditions^[1].
Brazzein (1–15 μM) shows weak anti-inflammatory activity in RAW 264.7 cells, with an IC₅₀ > 15 μM for NO production inhibition^[1].
Brazzein (1-15 μM) has no cytotoxic effect on RAW 264.7 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 178359-31-4
Peso molecular 6473.18
Fòrmula C₂₇₆H₄₁₀N₇₆O₈₉S₈
Sequence

Glp-Asp-Lys-Cys-Lys-Lys-Val-Tyr-Glu-Asn-Tyr-Pro-Val-Ser-Lys-Cys-Gln-Leu-Ala-Asn-Gln-Cys-Asn-Tyr-Asp-Cys-Lys-Leu-Asp-Lys-His-Ala-Arg-Ser-Gly-Glu-Cys-Phe-Tyr-Asp-Glu-Lys-Arg-Asn-Leu-Gln-Cys-Ile-Cys-Asp-Tyr-Cys-Glu-Tyr (disulfide bridge:Cys4-Cys52,Cys16-Cys37,Cys22-Cys47,Cys26-Cys49)
Sequence Shortening

Glp-DKCKKVYENYPVSKCQLANQCNYDCKLDKHARSGECFYDEKRNLQCICDYCEY (disulfide bridge:Cys4-Cys52,Cys16-Cys37,Cys22-Cys47,Cys26-Cys49)
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Chung JH, et al. Antioxidant, anti-inflammatory, and anti-allergic activities of the sweet-tasting protein brazzein. Food Chem. 2018;267:163-169. [Content Brief]

[2]. Martinez Raquel, et al. Brazzein as a sustainable alternative to sugar: production, perception, and public health impact. J Appl Biotechnol Bioeng. 2025;12(1):45-48.

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
Chemical Information
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Referencias

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Brazzein

Ver todos los productos específicos de isoformas COX