Brivekimig
Based on 1 Customer Validation
Brivekimig (F-027300252; SAR-442970) is a bispecific nanobody targeting TNF/OX40L. Brivekimig is applicable to research related to hidradenitis suppurativa.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 98%
- No. CAS: 2834733-45-6
- Peso molecular:66.21 kDa
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Almacenamiento:Shipping with dry ice
Please store the product under the recommended conditions in the Certificate of Analysis.
Ver todos los productos específicos de isoformas TNF Receptor
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Actividad biológica
Descripciòn
Isotype
VH-VH-VH-VH-VH
Species Reactivity
Human
In Vitro
Brivekimig simultaneously blocks TNF and OX40L, and exhibits superiority over Amlitelimab (HY-P99434) (an anti-OX40L antibody) in reducing infiltrating inflammatory cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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5VH
Aplicación
ELISA, FACS, Functional assay
Verified Bioactivity
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Loaded Brivekimig on AHC2 biosensor, can bind Serum Albumin/ALB Protein, Human (HEK293, His-Avi, HY-P78393) with an affinity constant of 3.668E-09 M as determined in BLI assay. -
Loaded Brivekimig on AHC2 biosensor, can bind TNF alpha protein, Human (His, HY-P70426A) with an affinity constant of <1.0E-12 M as determined in BLI assay. -
Flow cytometric analysis of 1X106 HUVEC cells with Brivekimig (HY-P990907, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
Chemical Information
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No. CAS 2834733-45-6
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Appearance Liquid
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Peso molecular 66.21 kDa
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Color Colorless to light yellow
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SMILES
[Brivekimig]
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Synonyms
F-027300252; SAR-442970
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Envío
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
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Ficha de datos (256 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)