BT173
Based on 1 Customer Validation
BT173 is a potent homeodomain interacting protein kinase 2 (HIPK2) inhibitor. BT173 binds to HIPK2 and does not inhibit HIPK2 kinase activity but rather, interfered allosterically with the ability of HIPK2 to associate with Smad3. BT173 attenuates renal fibrosis through suppression of the TGF-β1/Smad3 pathway. BT173 can be studied in research for kidney diseases such as renal fibrosis.
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- Pureza: 98.71%
- No. CAS: 2232180-74-2
- Fòrmula: C18H12BrN3O2
- Peso molecular:382.21
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Almacenamiento:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Actividad biológica
BT173 (0-10 μM) significantly attenuates the Smad3 activity in HEK 293T cells[1].
BT173 (10 μM) has effect on HIPK2 which leads to repression of TGF-β/Smad3-dependent gene transcription in HEK 293T cells[1].
BT173 (0-100 μM) results in a partial protection of HIPK2 from prognase digestion at 30 μM and a complete protection at 100 μM in HEK 293T cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HEK293T
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Concentration:0.3, 1, 3, 10, and 30 μM
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Incubation Time:16 h
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Result:Did not induce any significant increase of LDH level in the culture medium.
BT173 (20 mg/kg, p.o., 4 w) ameliorates proteinuria and kidney fibrosis in Tg26 mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:UUO C57BL/6J renal fibrosis mouse model[1]
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Dosage:20 mg/kg
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Administration:Oral gavage (p.o.)
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Result:Led to significant attenuation of fibrosis at 14 days postsurgery.
Significantly diminished the expression of genes in the Wnt/β-catenin pathways (Axin2, c-myc, and Twist).
Chemical Information
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No. CAS 2232180-74-2
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Appearance Solid
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Peso molecular 382.21
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Fòrmula C18H12BrN3O2
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Color White to light yellow
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SMILES
COC1=CC=C2C=C(C3=NC(C4=CC=C(Br)C=C4)=NO3)C=NC2=C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvente y solubilidad
DMSO : 2 mg/mL (5.23 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6164 mL | 13.0818 mL | 26.1636 mL | 65.4091 mL |
| 5 mM | 0.5233 mL | 2.6164 mL | 5.2327 mL | 13.0818 mL |
BT173 Related Classifications
HY-128439 Related Classifications
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