country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Referencia número: HY-10084

Copy Link Print Information

CK0106023

CK0106023 is a potent and specific allosteric inhibitor of KSP with a K_i value of 12 nM, showing antitumor activity. CK0106023 causes mitotic arrest and growth inhibition in several tumor cell lines. CK0106023 exhibits antitumor activity in tumor-bearing mice.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 336115-72-1
Fòrmula: C₃₀H₃₂BrClN₄O₂
Peso molecular:595.96

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

CK0106023 Chemical Structure

No. CAS: 336115-72-1

Tamaño

Precio

Stock

Cantidad

Amount: USD 0.00

* Seleccione Cantidad antes de agregar artículos.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Cellular Effect
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

Ver todos los productos específicos de isoformas Kinesin :

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	3 μM Compound: CK0106023	Cytotoxicity against human A2780 cells after 72 hrs by MTT assay Cytotoxicity against human A2780 cells after 72 hrs by MTT assay	[PMID: 20934346]
A549	IC₅₀	4.89 μM Compound: CK0106023	Cytotoxicity against human A549 cells after 48 hrs by SRB assay Cytotoxicity against human A549 cells after 48 hrs by SRB assay	[PMID: 21856161]
A549	IC₅₀	7.02 μM Compound: CK0106023	Antiproliferative activity against human A549 cells after 24 hrs by SRB assay Antiproliferative activity against human A549 cells after 24 hrs by SRB assay	[PMID: 20537544]
AGS	IC₅₀	5.1 μM Compound: CK0106023	Antiproliferative activity against human AGS cells after 24 hrs by SRB assay Antiproliferative activity against human AGS cells after 24 hrs by SRB assay	[PMID: 20537544]
AGS	IC₅₀	6.7 μM Compound: CK0106023	Cytotoxicity against human AGS cells after 48 hrs by SRB assay Cytotoxicity against human AGS cells after 48 hrs by SRB assay	[PMID: 21856161]
HCT-116	IC₅₀	0.94 μM Compound: CK0106023	Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay	[PMID: 20934346]
HepG2	IC₅₀	>10 μM Compound: CK0106023	Antiproliferative activity against human HepG2 cells after 24 hrs by SRB assay Antiproliferative activity against human HepG2 cells after 24 hrs by SRB assay	[PMID: 20537544]
HepG2	IC₅₀	2.1 μM Compound: CK0106023	Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay	[PMID: 20934346]
HT-29	IC₅₀	3.33 μM Compound: CK0106023	Antiproliferative activity against human HT-29 cells after 24 hrs by SRB assay Antiproliferative activity against human HT-29 cells after 24 hrs by SRB assay	[PMID: 20537544]
PC-3	IC₅₀	>10 μM Compound: CK0106023	Antiproliferative activity against human PC3 cells after 24 hrs by SRB assay Antiproliferative activity against human PC3 cells after 24 hrs by SRB assay	[PMID: 20537544]

Chemical Information

No. CAS 336115-72-1
Peso molecular 595.96
Fòrmula C₃₀H₃₂BrClN₄O₂
SMILES

O=C1N(CC2=CC=CC=C2)C(C(CC)N(CCCN(C)C)C(C(C=C3)=CC=C3Br)=O)=NC4=C1C=CC(Cl)=C4
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. You-Ling Fan. End-capped polyarylene polyethers, articles made therefrom and process for preparing such polyarylene polyethers. EP0106023B1. 1988 March 30.

[2]. Sakowicz R, et al. Antitumor activity of a kinesin inhibitor. Cancer Res. 2004 May 1;64(9):3276-80. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Obtener un presupuesto En stock

Other size

Obtener un presupuesto

Amount: USD 0.00

Actividad biológica
- Descripciòn
Chemical Information
Pureza y Documentación
Referencias

Nombre del producto:
Referencia número:
Cantidad:
MCE Japan Authorized Agent:

Nombre del producto:
No. CAS:
Species:
Pureza:
Cantidad:

CK0106023

Ver todos los productos específicos de isoformas Kinesin

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

CK0106023 Related Classifications

HY-10084 Related Classifications