DA-PROTAC
DA-PROTAC is a potent PROTAC degrader of copper ion-transport proteins Atox1 and CCS. DA-PROTAC can bind both Atox1 and CCS proteins, and the complex can be bound to E3 ligase, leading to increased levels of ubiquitination of Atox1 and CCS and degradation of Atox1 and CCS proteins via the proteasome pathway. DA-PROTAC can be used for triple negative breast cancer research.
(Pink: ATOX1 and CCS ligand (HY-184970); Blue: VHL ligand (HY-184971); Black: linker (HY-48450)).
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- No. CAS: 2488660-12-2
- Fòrmula: C46H50BrF2N7O8S2
- Peso molecular:1010.96
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
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VHL |
DA-PROTAC (0-1 μM, 24 h) can degrade Atox1 and CCS proteins rather than inhibit Atox1 and CCS activity[1].
DA-PROTAC (5 μM, 24 h) inhibits the proliferation, migration and invasion of triple negative breast cancer cells (MDA-MB-231)[1].
DA-PROTAC (10 μM, 48 h) inhibits the tumorigenic capacity of triple negative breast cancer cells (MDA-MB-231)[1].
The targeting module of DA-PROTAC is a small molecule VHL ligand1 combined with E3 ligase[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-231 cells
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Concentration:100 nM ,200 nM ,500 nM , and 1000 nM
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Incubation Time:24 h
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Result:Significantly reduced ATOX1 and CCS protein levels under 200nM, indicating that DA-PROTAC can degrade ATOX1 and CCS proteins.
Chemical Information
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No. CAS 2488660-12-2
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Peso molecular 1010.96
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Fòrmula C46H50BrF2N7O8S2
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SMILES
O=C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C3=C(N=CS3)C)C=C2)=O)C(C(C)(C)C)NC(COCCCOCC(NC4=C(C(NC5=C(C=C(C=C5F)F)Br)=O)SC6=C4C=C(CCC7)C7=N6)=O)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DA-PROTAC Related Classifications
HY-147373 Related Classifications
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