Elranatamab
Based on 1 Customer Validation
Elranatamab (PF-06863135) is an anti-CD3E/TNFRSF17 human IgG2κ monoclonal antibody. Recommend Isotype Controls: Human IgG2 kappa, Isotype Control (HY-P99002).
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- Pureza: 98.74%
- No. CAS: 2408850-14-4
- Peso molecular:145.441 kDa
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
Isotype
Human IgG2 kappa
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
CD3E & TNFRSF17
In Vitro
Elranatamab (0.1-10 nM, 2 days) exhibits cytotoxicity in L-363 myeloma cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:L-363
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Concentration:0.1-10 nM
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Incubation Time:2 days
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Result:Exhibited cytotoxicity
Ensayo clínico
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Human IgG2 kappa
Aplicación
ELISA, FACS, Functional assay
Verified Bioactivity
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Loaded BCMA/TNFRSF17 Trimer Protein, Human (Biotinylated, HEK293, His-Avi, HY-P78071) on NTA biosensor, can bind Elranatamab with an affinity constant of 2.432E-11 M as determined in BLI assay. -
Flow cytometric analysis of 1×106 Jurkat cells labelling CD3E (red) with Elranatamab (HY-P99909). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG2 kappa Isotype Control (HY-P99002, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
Chemical Information
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No. CAS 2408850-14-4
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Appearance Liquid
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Peso molecular 145.441 kDa
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Color Colorless to light yellow
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SMILES
[Elranatamab]
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Synonyms
PF-06863135; RN-613
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Envío
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
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Ficha de datos (254 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
Referencias
[1]. Elranatamab
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)