Ethyl glucuronide
Based on 1 Customer Validation
Ethyl glucuronide is an endogenous metabolite. Ethyl glucuronide is the metabolite of ethanol. Ethyl glucuronide is a biomarker for ethanol exposure that accumulates in hair and reflects the alcohol intake over a time period. Ethyl glucuronide is the agonist for TLR4.
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- Pureza: 99.22%
- No. CAS: 17685-04-0
- Fòrmula: C8H14O7
- Peso molecular:222.19
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Almacenamiento:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Actividad biológica
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Human Endogenous Metabolite |
Ethyl glucuronide (0-100 μM, 24 h) blocks the formation of TLR4-MD2 complex, stimulates the expression of TLR4-depenent SEAP protein in HEK-TLR4 cell[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley rat models[2]
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Dosage:0.38 µg
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Administration:intrathecal injection, single dose
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Result:Reduced the tactile threshold.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 17685-04-0
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Appearance Solid
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Peso molecular 222.19
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Fòrmula C8H14O7
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Color White to off-white
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SMILES
OC([C@@H]1[C@H]([C@@H]([C@@H](O)[C@H](OCC)O1)O)O)=O
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvente y solubilidad
H2O : 125 mg/mL (562.57 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (277 KB)
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SDS (394 KB)
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- Français - FR (394 KB)
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- Español - ES (394 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Małkowska A, et al., The influence of caffeine on ethyl glucuronide levels in rat serum and in rat hair. Pharmacol Rep. 2018 Oct;70(5):831-836. [Content Brief]
[2]. Lewis SS, et al., Glucuronic acid and the ethanol metabolite ethyl-glucuronide cause toll-like receptor 4 activation and enhanced pain. Brain Behav Immun. 2013 May;30:24-32. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 4.5006 mL | 22.5030 mL | 45.0059 mL | 112.5148 mL |
| 5 mM | 0.9001 mL | 4.5006 mL | 9.0012 mL | 22.5030 mL | |
| 10 mM | 0.4501 mL | 2.2503 mL | 4.5006 mL | 11.2515 mL | |
| 15 mM | 0.3000 mL | 1.5002 mL | 3.0004 mL | 7.5010 mL | |
| 20 mM | 0.2250 mL | 1.1251 mL | 2.2503 mL | 5.6257 mL | |
| 25 mM | 0.1800 mL | 0.9001 mL | 1.8002 mL | 4.5006 mL | |
| 30 mM | 0.1500 mL | 0.7501 mL | 1.5002 mL | 3.7505 mL | |
| 40 mM | 0.1125 mL | 0.5626 mL | 1.1251 mL | 2.8129 mL | |
| 50 mM | 0.0900 mL | 0.4501 mL | 0.9001 mL | 2.2503 mL | |
| 60 mM | 0.0750 mL | 0.3750 mL | 0.7501 mL | 1.8752 mL | |
| 80 mM | 0.0563 mL | 0.2813 mL | 0.5626 mL | 1.4064 mL | |
| 100 mM | 0.0450 mL | 0.2250 mL | 0.4501 mL | 1.1251 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Ethyl glucuronide Related Classifications
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