FLDP-5
FLDP-5 is a blood-brain barrier (BBB) penetrant curcuminoid analogues. FLDP-5 can induce production of ROS (Reactive Oxygen Species), DNA damage and cell cycle S phase arrest. FLDP-5 exhibits highly potent tumour-suppressive effects with anti-proliferative and anti-migratory activities on LN-18 cells.
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- No. CAS: 950665-12-0
- Fòrmula: C21H21NO5
- Peso molecular:367.40
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Almacenamiento:
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| C6 | IC50 |
3.9 μM
Compound: 14
|
Antiproliferative activity against rat C6 cells after 72 hrs by MTT assay
Antiproliferative activity against rat C6 cells after 72 hrs by MTT assay
|
[PMID: 20831222] |
| Caco-2 | IC50 |
0.2 μM
Compound: 14
|
Antiproliferative activity against human Caco-2 cells after 72 hrs by MTT assay
Antiproliferative activity against human Caco-2 cells after 72 hrs by MTT assay
|
[PMID: 20831222] |
| HaCaT | IC50 |
3 μM
Compound: 14
|
Antiproliferative activity against human HaCaT cells after 72 hrs by MTT assay
Antiproliferative activity against human HaCaT cells after 72 hrs by MTT assay
|
[PMID: 20831222] |
| HT-22 | IC50 |
3.1 μM
Compound: 14
|
Antiproliferative activity against mouse HT22 cells after 72 hrs by MTT assay
Antiproliferative activity against mouse HT22 cells after 72 hrs by MTT assay
|
[PMID: 20831222] |
| NB-4 | IC50 |
0.4 μM
Compound: 231
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Cytotoxicity against human NB4 cells assessed as reduction in cell viability after 72 hrs by MTS assay
Cytotoxicity against human NB4 cells assessed as reduction in cell viability after 72 hrs by MTS assay
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[PMID: 24960549] |
| NIH3T3 | IC50 |
4.2 μM
Compound: 14
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Antiproliferative activity against BALB/c mouse 3T3 cells after 72 hrs by MTT assay
Antiproliferative activity against BALB/c mouse 3T3 cells after 72 hrs by MTT assay
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[PMID: 20831222] |
| SH-SY5Y | IC50 |
2.1 μM
Compound: 14
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Antiproliferative activity against human SH-SY5Y cells after 72 hrs by MTT assay
Antiproliferative activity against human SH-SY5Y cells after 72 hrs by MTT assay
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[PMID: 20831222] |
FLDP-5 (0-20 μM; 24 h) has cytotoxicity on human glioblastoma multiforme (GBM) LN-18 cells and HBEC-5i[1].
FLDP-5 (2.5 μM; 0-6 h) induces superoxide and hydrogen peroxide in LN-18 cell death[1].
FLDP-5 (2.5 μM; 0-4 h) induces DNA damage with a time-dependent manner in LN-18 cells[1].
FLDP-5 (1.25 and 2.5 μM; 24 and 48 h) potentiates anti-migration effects in LN-18 cells[1].
FLDP-5 (1.25 and 2.5 μM; 24 h) reduces the percentage of relative invasion in LN-18 cells in a significant dose-dependent manner[1].
FLDP-5 (0.625 and 1.25 μM; 24 h) induces arrest in S phase in a concentration-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:LN-18 and HBEC-5i cells
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Concentration:0-20 μM
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Incubation Time:24 h
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Result:Exhibited cytotoxicity on human GBM LN-18 cells and HBEC-5i with IC50s of 2.4 μM and 5.6 μM.
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Cell Line:LN-18 cells
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Concentration:1.25 and 2.5 μM
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Incubation Time:24 and 48 h
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Result:Potentiated anti-migration effects in LN-18 cells with wound closure of 56.43% ± 6.28 and 3.17% ± 0.71 at 1.25 μM and 2.5 μM (48 h), respectively.
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Cell Line:LN-18 cells
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Concentration:1.25 and 2.5 μM
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Incubation Time:24 h
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Result:Reduced the percentage of relative invasion in LN-18 cells in a significant dose-dependent manner.
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Cell Line:LN-18 cells
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Concentration:0.625 and 1.25 μM
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Incubation Time:24 h
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Result:Induced arrest in S phase in a concentration-dependent manner, and exhibited accumulation of 63.38% ± 4.42 at 1.25 μM.
Chemical Information
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No. CAS 950665-12-0
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Peso molecular 367.40
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Fòrmula C21H21NO5
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SMILES
O=C1/C(CNC/C1=C\C2=CC=C(O)C(OC)=C2)=C/C3=CC=C(O)C(OC)=C3
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FLDP-5 Related Classifications
HY-150791 Related Classifications
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