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Referencia número: HY-152838

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Gemlapodect

Name: Gemlapodect
Brand: MedChemExpress
SKU: HY-152838
Availability: PreOrder

(Synonyms: RO554965)

Gemlapodect (RO554965) is an inhibitor of phosphodiesterase 10A (PDE10A). Gemlapodect can be used for researching schizophrenia.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 1380329-87-2
Fòrmula: C₂₂H₂₁N₇O₃
Peso molecular:431.45

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Gemlapodect Chemical Structure

No. CAS: 1380329-87-2

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Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vivo
- Ensayo clínico
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
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Actividad biológica

Descripciòn

Gemlapodect (RO554965) is an inhibitor of phosphodiesterase 10A (PDE10A). Gemlapodect can be used for researching schizophrenia^[1].

IC₅₀ & Target^[1]

PDE10A

Ver todos los productos específicos de isoformas Phosphodiesterase (PDE) :

In Vivo

Gemlapodect (5-15 mg; p.o.; once daily for 6 weeks) significantly improves the work and life social functions of Childhood-Onset Fluency Disorder (COFD) patients and shows biosafety^[2].
Gemlapodect (10 mg/kg; p.o.; single dose) shows nothing change in glucose tolerance of 9 weeks male SD rats^[2].
Gemlapodect (0.3 mg/kg; p.o.; once daily for 8 days) induces a slight glucose tolerance improvement, no changes in fasting blood glucose, and decreases of fasting insulin in 10 weeks male SD rats^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Adult male patients with COFD (18-50 years old)^[2].
Dosage:

5-15 mg.
Administration:

Oral gavage; once daily for 6 weeks.
Result:

Improved the Stuttering, work, social life, family life and home responsibilities of COFD patients and showed biosafety.

Animal Model:

9 weeks or 10 weeks male SD rats^[2].
Dosage:

0.3 mg/kg or 10 mg/kg.
Administration:

Oral gavage; once daily for 1 or 8 days.
Result:

Showed insignificantly change of glucose tolerance in healthy rats.

Ensayo clínico

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

No. CAS 1380329-87-2
Peso molecular 431.45
Fòrmula C₂₂H₂₁N₇O₃
SMILES

O=C(C1=C(C(N2CCOCC2)=O)C=NN1C)NC3=CC4=NC(C5=CC=CC=C5)=NN4C=C3
Synonyms

RO554965
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Zagorska A, et al. Phosphodiesterase 10 Inhibitors - Novel Perspectives for Psychiatric and Neurodegenerative Drug Discovery. Curr Med Chem. 2018;25(29):3455-3481. [Content Brief]

[2]. GARIBALDI, et al. METHODS FOR THE TREATMENT OF CHILDHOOD-ONSET FLUENCY DISORDER. World Intellectual Property Organization. WO2022162193

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vivo
- Ensayo clínico
Chemical Information
Pureza y Documentación
Referencias

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Gemlapodect

Ver todos los productos específicos de isoformas Phosphodiesterase (PDE)