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Referencia número: HY-138990

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GK563

GK563 is a selective Ca²⁺-independent phospholipase A₂ (GVIA iPLA₂) inhibitor with an IC₅₀ value of 1 nM. GK563 is 22000 times more active against GVIA iPLA₂ than GIVA cPLA₂. GK563 reduces β-cell apoptosis induced by proinflammatory cytokines, raising the possibility that it can be beneficial in countering autoimmune diseases, such as type 1 diabetes.

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No. CAS: 2351820-19-2
Fòrmula: C₁₆H₂₂O₂
Peso molecular:246.34

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

GK563 Chemical Structure

No. CAS: 2351820-19-2

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
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Actividad biológica

Descripciòn

IC₅₀ & Target

IC50: 1 nM (GVIA iPLA2), 22 μM (GVIA cPLA2)^[1]

Ver todos los productos específicos de isoformas Phospholipase :

In Vitro

GK563 (0.091 M) inhibits the activity of 100% GVIA iPLA₂, 88% GVIA cPLA₂ and 25% GV sPLA₂^[1].
GK563 (0-0.1 μM) inhibits GVIA iPLA₂ with a X_I(50) value of 0.0000021 and inhibits GVIA cPLA₂ with an IC₅₀ value of 22 μM^[1].
GK563 (0-0.1 μM) shows a better inhibitory effect than fluoroketone FKGK18 to GVIA iPLA₂ with an IC₅₀ value of 1 nM^[1].
GK563 (0-0.1 μM; 16 h) reduces β-cell apoptosis induced by proinflammatory cytokines^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:

β-cell line
Concentration:

0.1-10 μM
Incubation Time:

16 h
Result:

Promoted a slight but modest rise in cell death when worked alone, but produced a concentration-dependent inhibition of β-cell apoptosis by the co-treatment of cells with cytokines.

Chemical Information

No. CAS 2351820-19-2
Peso molecular 246.34
Fòrmula C₁₆H₂₂O₂
SMILES

CCC[C@H]1[C@@H](C(O1)=O)CCCCC2=CC=CC=C2
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Dedaki C, et al. β-Lactones: A Novel Class of Ca2+-Independent Phospholipase A2 (Group VIA iPLA2) Inhibitors with the Ability To Inhibit β-Cell Apoptosis. J Med Chem. 2019 Mar 28;62(6):2916-2927. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Actividad biológica
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- IC₅₀ & Target
- In Vitro
Chemical Information
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GK563

Ver todos los productos específicos de isoformas Phospholipase

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

GK563 Related Classifications

HY-138990 Related Classifications