HEI3090
Based on 1 publication(s) in Google Scholar
HEI3090 is a P2X7R activator. HEI3090 stimulates dendritic cells expressing P2X7R to produce IL-18, which subsequently promotes Natural Killer cells and CD4 T cells within tumors to produce IFN-γ, leading to a sustained antitumor response. HEI3090 can be used to enhance the efficacy of αPD-1 therapy in non-small cell lung cancer (NSCLC).
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.00%
- No. CAS: 2377167-56-9
- Fòrmula: C18H15Cl3N4O3
- Peso molecular:441.70
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) HEI3090
MoreVer todos los productos específicos de isoformas P2X Receptor
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Actividad biológica
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P2X7 Receptor |
Chemical Information
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No. CAS 2377167-56-9
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Appearance Solid
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Peso molecular 441.70
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Fòrmula C18H15Cl3N4O3
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Color White to off-white
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SMILES
ClC1=NC=C(C=C1)NC(N2[C@@H](CCC2=O)C(NCC3=C(C=C(C=C3)Cl)Cl)=O)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Int Immunopharmacol
CGRP alleviates epilepsy via JAK1-STAT1-P2RX7 signaling: a novel neuroprotective axis targeting neuronal damage. [Abstract]2025 Dec 21:170:116080. PMID: 41429063
Solvente y solubilidad
DMSO : 50 mg/mL (113.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2640 mL | 11.3199 mL | 22.6398 mL | 56.5995 mL |
| 5 mM | 0.4528 mL | 2.2640 mL | 4.5280 mL | 11.3199 mL | |
| 10 mM | 0.2264 mL | 1.1320 mL | 2.2640 mL | 5.6600 mL | |
| 15 mM | 0.1509 mL | 0.7547 mL | 1.5093 mL | 3.7733 mL | |
| 20 mM | 0.1132 mL | 0.5660 mL | 1.1320 mL | 2.8300 mL | |
| 25 mM | 0.0906 mL | 0.4528 mL | 0.9056 mL | 2.2640 mL | |
| 30 mM | 0.0755 mL | 0.3773 mL | 0.7547 mL | 1.8867 mL | |
| 40 mM | 0.0566 mL | 0.2830 mL | 0.5660 mL | 1.4150 mL | |
| 50 mM | 0.0453 mL | 0.2264 mL | 0.4528 mL | 1.1320 mL | |
| 60 mM | 0.0377 mL | 0.1887 mL | 0.3773 mL | 0.9433 mL | |
| 80 mM | 0.0283 mL | 0.1415 mL | 0.2830 mL | 0.7075 mL | |
| 100 mM | 0.0226 mL | 0.1132 mL | 0.2264 mL | 0.5660 mL |
HEI3090 Related Classifications
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