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Referencia número: HY-139784

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Idroxioleic acid

Name: Idroxioleic acid
Brand: MedChemExpress
SKU: HY-139784
Availability: PreOrder

(Synonyms: (R)-2-Hydroxyoleic acid; (R)-2-OHOA; (R)-LAM561)

Idroxioleic acid ((R)-2-Hydroxyoleic acid; (R)-2-OHOA), the R enantiomer of (Rac)-Idroxioleic acid, is an orally active fatty acid that modulates the lipid composition and structure of the membranes. Idroxioleic acid has antitumor activities.

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No. CAS: 182370-45-2
Fòrmula: C₁₈H₃₄O₃
Peso molecular:298.46

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (262 KB)

Idroxioleic acid Chemical Structure

No. CAS: 182370-45-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- In Vitro
- In Vivo
Chemical Information
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Actividad biológica

Descripciòn

Ver todos los productos específicos de isoformas Endogenous Metabolite :

In Vitro

Idroxioleic acid ((R)-2-Hydroxyoleic acid; (R)-2-OHOA) inhibited the growth of A549, lung adenocarcinoma cell line with an IC₅₀ of 252 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Idroxioleic acid ((R)-2-Hydroxyoleic acid; (R)-2-OHOA; 400 mg/kg; p.o.; daily; for 21 days) causes a reduction in tumor volume of about 20-25% after 21 days^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male NUDE (Swiss) Crl:NU(Ico)-Foxn1nu mice (5 weeks old, 30-35 g) injected with A549 human lung cancer cells^[1]
Dosage:

400 mg/kg
Administration:

p.o.; daily; for 21 days
Result:

Caused a reduction in tumor volume of about 20-25% after 21 days.

Chemical Information

No. CAS 182370-45-2
Peso molecular 298.46
Fòrmula C₁₈H₃₄O₃
SMILES

OC([C@H](O)CCCCCC/C=C\CCCCCCCC)=O
Synonyms

(R)-2-Hydroxyoleic acid; (R)-2-OHOA; (R)-LAM561
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (262 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Stefano Piotto, et al. Differential effect of 2-hydroxyoleic acid enantiomers on protein (sphingomyelin synthase) and lipid (membrane) targets. Biochim Biophys Acta. 2014 Jun;1838(6):1628-37. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Chemical Information
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Idroxioleic acid

Ver todos los productos específicos de isoformas Endogenous Metabolite