Iodophenpropit dihydrobromide
Based on 1 Customer Validation
Iodophenpropit dihydrobromide is a potent and selective histamine H3 receptor antagonist. The binding of [125I]Iodophenpropit is selective, saturable, readily reversible, and of high affinity (KD 0.32 nM).
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- Pureza: 99.70%
- No. CAS: 145196-87-8
- Fòrmula: C15H21Br2IN4S
- Peso molecular:576.13
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Almacenamiento:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
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Ver todos los productos específicos de isoformas Histamine Receptor
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Actividad biológica
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H3 Receptor 0.32 nM (Kd) |
Iodophenpropit is a very potent H3 receptor antagonist and shows only a moderate affinity for the H1 and H2 receptor[2].
Iodophenpropit inhibit 5-hydroxytryptamine (5-HT) responses with an IC50 of 1.57±0.3 μM[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:New Zealand adult healthy rabbits of either sex weighing 1.63±0.36 kg[4]
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Dosage:1 μg/kg
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Administration:Administered through intramuscular (i.m.); b.i.d.; for 10 days
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Result:Could influence a detectable antibody response to SRBC.
Chemical Information
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No. CAS 145196-87-8
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Appearance Solid
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Peso molecular 576.13
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Fòrmula C15H21Br2IN4S
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Color White to off-white
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SMILES
N=C(SCCCC1=CNC=N1)NCCC2=CC=C(I)C=C2.[H]Br.[H]Br
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvente y solubilidad
DMSO : 57.6 mg/mL (99.98 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Jansen FP, et al. The first radiolabeled histamine H3 receptor antagonist, [125I]Iodophenpropit: saturable and reversible binding to rat cortex membranes. Eur J Pharmacol. 1992 Jul 7;217(2-3):203-5. [Content Brief]
[2]. Leurs R, et al. Evaluation of the receptor selectivity of the H3 receptor antagonists, Iodophenpropit and thioperamide: an interaction with the 5-HT3 receptor revealed. Br J Pharmacol. 1995 Oct;116(4):2315-21. [Content Brief]
[3]. Allen MC. Agonist and antagonist effects of histamine H3 receptor ligands on 5-HT3 receptor-mediated ion currents in NG108-15 cells. Eur J Pharmacol. 1998 Nov 20;361(2-3):261-8. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7357 mL | 8.6786 mL | 17.3572 mL | 43.3930 mL |
| 5 mM | 0.3471 mL | 1.7357 mL | 3.4714 mL | 8.6786 mL | |
| 10 mM | 0.1736 mL | 0.8679 mL | 1.7357 mL | 4.3393 mL | |
| 15 mM | 0.1157 mL | 0.5786 mL | 1.1571 mL | 2.8929 mL | |
| 20 mM | 0.0868 mL | 0.4339 mL | 0.8679 mL | 2.1696 mL | |
| 25 mM | 0.0694 mL | 0.3471 mL | 0.6943 mL | 1.7357 mL | |
| 30 mM | 0.0579 mL | 0.2893 mL | 0.5786 mL | 1.4464 mL | |
| 40 mM | 0.0434 mL | 0.2170 mL | 0.4339 mL | 1.0848 mL | |
| 50 mM | 0.0347 mL | 0.1736 mL | 0.3471 mL | 0.8679 mL | |
| 60 mM | 0.0289 mL | 0.1446 mL | 0.2893 mL | 0.7232 mL | |
| 80 mM | 0.0217 mL | 0.1085 mL | 0.2170 mL | 0.5424 mL |
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