Isogarcinol
Based on 1 publication(s) in Google Scholar
Isogarcinol (Cambogin) is a potent AChE and BChE inhibitor, with IC50 values of 1.13 and 8.30 μM, respectively. Isogarcinol also shows leishmanicidal activity, with an IC50 of 0.33 μM against L. donovani.
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- No. CAS: 71117-97-0
- Fòrmula: C38H50O6
- Peso molecular:602.80
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Isogarcinol
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Actividad biológica
Descripciòn
IC50 & Target
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AChE 1.13 ± 0.0 μM (IC50) |
BChE 8.30 ± 0.0 μM (IC50) |
Leishmania 0.33 μM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
19.21 μM
Compound: 1
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Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
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[PMID: 30500683] |
| HEL | IC50 |
9.24 μM
Compound: 1
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Antiproliferative activity against HEL cells after 72 hrs by MTT assay
Antiproliferative activity against HEL cells after 72 hrs by MTT assay
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[PMID: 30500683] |
| HeLa | IC50 |
16.46 μM
Compound: 1
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Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay
Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay
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[PMID: 30500683] |
| HepG2 | IC50 |
7.3 μM
Compound: 9
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Cytotoxicity against human HepG2 cells by MTT assay
Cytotoxicity against human HepG2 cells by MTT assay
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[PMID: 24960143] |
| K562 | IC50 |
14.1 μM
Compound: 1
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Antiproliferative activity against human K562 cells after 72 hrs by MTT assay
Antiproliferative activity against human K562 cells after 72 hrs by MTT assay
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[PMID: 30500683] |
| L02 | IC50 |
9.3 μM
Compound: 9
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Cytotoxicity against human HL7702 cells by MTT assay
Cytotoxicity against human HL7702 cells by MTT assay
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[PMID: 24960143] |
| MCF7 | IC50 |
10.24 μM
Compound: 1
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Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
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[PMID: 30500683] |
| MCF7 | IC50 |
4.8 μM
Compound: 9
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Cytotoxicity against human MCF7 cells by MTT assay
Cytotoxicity against human MCF7 cells by MTT assay
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[PMID: 24960143] |
| MDA-MB-231 | IC50 |
5.7 μM
Compound: 9
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Cytotoxicity against human MDA-MB-231 cells by MTT assay
Cytotoxicity against human MDA-MB-231 cells by MTT assay
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[PMID: 24960143] |
| RAW264.7 | IC50 |
19.2 μM
Compound: 9
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Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of IFN-gamma plus LPS-induced NO production
Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of IFN-gamma plus LPS-induced NO production
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[PMID: 24960143] |
| U-251 | IC50 |
2.8 μM
Compound: 8
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Cytotoxicity against human U251MG cells assessed as reduction in cell viability after 72 hrs by CyQuant dye-based assay
Cytotoxicity against human U251MG cells assessed as reduction in cell viability after 72 hrs by CyQuant dye-based assay
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[PMID: 28729053] |
Chemical Information
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No. CAS 71117-97-0
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Appearance Solid
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Peso molecular 602.80
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Fòrmula C38H50O6
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SMILES
O=C1[C@@]23C(OC(C)([C@H](C3)C/C=C(C)\C)C)=C(C([C@@]1(C(C)([C@@H](C2)C/C=C(C)\C)C)C/C=C(C)\C)=O)C(C4=CC(O)=C(C=C4)O)=O
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Synonyms
Cambogin
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Cell Biochem Biophys
Isogarcinol Reduces MARS Levels and Deactivates the PI3K/AKT Pathway to Suppress the Malignant Properties of Breast Cancer Cells. [Abstract]2025 Mar 22. PMID: 40120049
Pureza y Documentación
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Ficha de datos (273 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Isogarcinol Related Classifications
HY-127087 Related Classifications
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