KB02
KB02 is a DCAF16-recruiting ligand that covalently binds to a ligandable cysteine on DCAF16, recruiting the E3 ligase to mediate target protein degradation. KB02 serves as a DCAF16-binding fragment for the synthesis of SHP2 PROTACs.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 62265-73-0
- Fòrmula: C11H12ClNO2
- Peso molecular:225.67
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Actividad biológica
Descripciòn
IC50 & Target
|
DCAF16 |
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:HeLa
-
Concentration:7.5 μM
-
Incubation Time:24 h
-
Result:Lacked the capability to induce SHP2 degradation.
Significantly inhibited SK8-induced SHP2 degradation.\nDid not induce SHP2 degradation.
Significantly inhibited SK8-induced SHP2 degradation.
Chemical Information
-
No. CAS 62265-73-0
-
Peso molecular 225.67
-
Fòrmula C11H12ClNO2
-
SMILES
OC1=CC=C(N(C(CCl)=O)CCC2)C2=C1
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KB02 Related Classifications
HY-189472 Related Classifications
Powered by Bioz