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Referencia número: HY-148277

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KTX-612

KTX-612 is an orally active IRAK4 PROTAC degrader with a DC₅₀ value of 7 nM. KTX-612 can be used for the research of oncology.
(Pink: IRAK4 ligand (HY-150735); Blue: Cereblon ligand (HY-10984); Black: linker).

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 2573298-14-1
Fòrmula: C₄₆H₅₁F₃N₈O₆
Peso molecular:868.94

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

KTX-612 Chemical Structure

No. CAS: 2573298-14-1

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Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

KTX-612 is an orally active IRAK4 PROTAC degrader with a DC₅₀ value of 7 nM. KTX-612 can be used for the research of oncology^[1]. (Pink: IRAK4 ligand (HY-150735); Blue: Cereblon ligand (HY-10984); Black: linker).

IC₅₀ & Target

IRAK4

7 nM (DC₅₀)

Ver todos los productos específicos de isoformas PROTACs :

Ver todos los productos específicos de isoformas IRAK :

Cellular Effect

Cell Line	Type	Value	Description	References
OCI-Ly10	IC₅₀	8 nM Compound: 24	Antiproliferative activity against human OCI-Ly10 cells measured after 4 days by CellTiter-Glo Luminescent Cell Viability Assay Antiproliferative activity against human OCI-Ly10 cells measured after 4 days by CellTiter-Glo Luminescent Cell Viability Assay	[PMID: 38920289]

In Vitro

KTX-612 has activity for IRAK4 with a DC₅₀ value of 7 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

KTX-612 (oral; 10 mg/kg) impacts oral absorption^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Rat^[1]
Dosage:

10 mg/kg
Administration:

Oral
Result:

Rat PO PK (10 mg/kg) KTX-612

%F 1

AUC(μM*hr) 0.060

Chemical Information

No. CAS 2573298-14-1
Peso molecular 868.94
Fòrmula C₄₆H₅₁F₃N₈O₆
SMILES

CC(C)(O)C1=CC2=NN(C=C2C=C1NC(C3=CC=CC(C(F)(F)F)=N3)=O)[C@H](CC4)CC[C@@H]4CN(CC5)CCC5(C6)CC6CNC7=C8C(C(N(C9C(NC(CC9)=O)=O)C8=O)=O)=CC=C7
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Discovery and characterization of IRAKIMiDs: degraders targeting both IRAK4 and IMiD substrates for oncology indications.

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureza y Documentación
Referencias

Nombre del producto:
Referencia número:
Cantidad:
MCE Japan Authorized Agent:

Nombre del producto:
No. CAS:
Species:
Pureza:
Cantidad:

Rat PO PK (10 mg/kg)	KTX-612
%F	1
AUC(μM*hr)	0.060

KTX-612

Ver todos los productos específicos de isoformas PROTACs

Ver todos los productos específicos de isoformas IRAK