Lecimibide
Lecimibide (DuP 128) is a potent and specific acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor for antihyperlipidemia research.
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- No. CAS: 130804-35-2
- Fòrmula: C34H40F2N4OS
- Peso molecular:590.77
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Help & FAQs
Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| J774 | IC50 |
1000 nM
Compound: 1
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Concentration required to inhibit 50% activity of J774 macrophage cholesterol esterification
Concentration required to inhibit 50% activity of J774 macrophage cholesterol esterification
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[PMID: 7707310] |
| Macrophage | IC50 |
1 μM
Compound: table I
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Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT) in J774 Macrophage cell culture by using J774 assay.
Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT) in J774 Macrophage cell culture by using J774 assay.
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10.1016/0960-894X(95)00001-A |
| Macrophage | IC50 |
1 μM
Compound: DuP-128
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Inhibition of Acyl coenzyme A:cholesterol acyltransferase in J774 Macrophage cell culture
Inhibition of Acyl coenzyme A:cholesterol acyltransferase in J774 Macrophage cell culture
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10.1016/0960-894X(95)00003-C |
Lecimibide (DuP 128)(10 μM, 24 h) can inhibit 85% of the cellular esterification reaction in HepG2 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 130804-35-2
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Peso molecular 590.77
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Fòrmula C34H40F2N4OS
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SMILES
O=C(NC1=CC=C(F)C=C1F)N(CCCCCSC2=NC(C3=CC=CC=C3)=C(C4=CC=CC=C4)N2)CCCCCCC
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Synonyms
DuP 128
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. L J Wilcox, et al. Secretion of hepatocyte apoB is inhibited by the flavonoids, naringenin and hesperetin, via reduced activity and expression of ACAT2 and MTP. J Lipid Res. 2001 May;42(5):725-34. [Content Brief]
[2]. J R Burnett, et al. Inhibition of cholesterol esterification by DuP 128 decreases hepatic apolipoprotein B secretion in vivo: effect of dietary fat and cholesterol. Biochim Biophys Acta. 1998 Jul 31;1393(1):63-79. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Lecimibide Related Classifications
HY-16281 Related Classifications
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