Melatonin-d3
Based on 1 Customer Validation
Melatonin-d3 is the deuterium labeled Melatonin. Melatonin is a hormone made by the pineal gland that can activates melatonin receptor. Melatonin plays a role in sleep and possesses important antioxidative and anti-inflammatory properties. Melatonin is a novel selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation. Melatonin attenuates palmitic acid-induced (HY-N0830) mouse granulosa cells apoptosis via endoplasmic reticulum stress.
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- Pureza: 99.15%
- No. CAS: 90735-69-6
- Fòrmula: C13H13D3N2O2
- Peso molecular:235.30
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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No. CAS 90735-69-6
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Unlabeled Cas 73-31-4
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Appearance Solid
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Peso molecular 235.30
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Fòrmula C13H13D3N2O2
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Color Pale purple to purple
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SMILES
O=C(NCCC1=CNC2=C1C=C(OC)C=C2)C([2H])([2H])[2H]
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Synonyms
N-Acetyl-5-methoxytryptamine-d3
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 100 mg/mL (424.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Kilic U, et al. Particular phosphorylation of PI3K/Akt on Thr308 via PDK-1 and PTEN mediates melatonin's neuroprotective activity after focal cerebral ischemia in mice. Redox Biol. 2017 Apr 5;12:657-665 [Content Brief]
[3]. Hu C, et al. Neuroprotective effect of melatonin on soluble Aβ1-42-induced cortical neurodegeneration via Reelin-Dab1 signaling pathway. Neurol Res. 2017 Apr 7:1-1 [Content Brief]
[4]. Rahim I, et al. Melatonin administration to wild-type mice and non-treated NLRP3 mutant mice share similar inhibition of the inflammatory response during sepsis. J Pineal Res. 2017 Mar 31 [Content Brief]
[5]. Bu LJ, et al. Melatonin, a novel selective ATF-6 inhibitor, induces human hepatoma cell apoptosis through COX-2 downregulation. World J Gastroenterol. 2017 Feb 14;23(6):986-998. [Content Brief]
[6]. Zhi Chen, et al. Melatonin attenuates palmitic acid-induced mouse granulosa cells apoptosis via endoplasmic reticulum stress. J Ovarian Res. 2019 May 10;12(1):43. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.2499 mL | 21.2495 mL | 42.4989 mL | 106.2473 mL |
| 5 mM | 0.8500 mL | 4.2499 mL | 8.4998 mL | 21.2495 mL | |
| 10 mM | 0.4250 mL | 2.1249 mL | 4.2499 mL | 10.6247 mL | |
| 15 mM | 0.2833 mL | 1.4166 mL | 2.8333 mL | 7.0832 mL | |
| 20 mM | 0.2125 mL | 1.0625 mL | 2.1249 mL | 5.3124 mL | |
| 25 mM | 0.1700 mL | 0.8500 mL | 1.7000 mL | 4.2499 mL | |
| 30 mM | 0.1417 mL | 0.7083 mL | 1.4166 mL | 3.5416 mL | |
| 40 mM | 0.1062 mL | 0.5312 mL | 1.0625 mL | 2.6562 mL | |
| 50 mM | 0.0850 mL | 0.4250 mL | 0.8500 mL | 2.1249 mL | |
| 60 mM | 0.0708 mL | 0.3542 mL | 0.7083 mL | 1.7708 mL | |
| 80 mM | 0.0531 mL | 0.2656 mL | 0.5312 mL | 1.3281 mL | |
| 100 mM | 0.0425 mL | 0.2125 mL | 0.4250 mL | 1.0625 mL |
Melatonin-d3 Related Classifications
HY-B0075S1 Related Classifications
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