MIPS3526
MIPS3526 is a potent and selective A2B adenosine receptor (A2BR) agonist with a pEC50 of 10.17 (EC50 of 58 pM). MIPS3526 shows highly receptor subtype selective versus the A1R, A2AR, and A3R. MIPS3526 ameliorates angiotensin II stimulating effects in both cardiac myocytes and fibroblasts. MIPS3526 can be used for the study of cardiovascular disease including heart failure where cardiac remodeling is a major driver.
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- Fòrmula: C44H43F3N10O5S
- Peso molecular:880.94
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Ver todos los productos específicos de isoformas Adenosine Receptor
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Actividad biológica
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A2BR 10.24 (pEC50) |
A2BR 58 pM (EC50) |
A1AR 7.08 (pEC50) |
A2AR 6.72 (pEC50) |
A3R 5.48 (pEC50) |
MIPS3526 (compound 7; 1-10 μM) ameliorates angiotensin II-induced neonatal rat cardiomyocyte (NCM) hypertrophywas[1].
\r\nMIPS3526 (1-10 μM) attenuates TGFβ-stimulated collagen synthesis in cardiac fibroblasts[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Peso molecular 880.94
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Fòrmula C44H43F3N10O5S
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SMILES
NC(S1)=C(C(C2=CC=CC=C2)=O)C(C3=CC(C(F)(F)F)=CC=C3)=C1C(C=C4)=CC=C4C(N=N5)=CN5CCCCCCNC6=NC=NC7=C6N=CN7[C@@H]8O[C@H](C(NCC)=O)[C@@H](O)[C@H]8O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MIPS3526 Related Classifications
HY-179277 Related Classifications
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