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United States

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Referencia número: HY-181121

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MK175

MK175 is an IL-1β inhibitor. MK175 reduces LPS (HY-D1056)-induced IL-1β release in human aortic smooth muscle cells. MK175 is applicable to the research of cardiovascular inflammatory diseases such as atherosclerosis.

Para uso exclusivo en investigación. No vendemos a pacientes.

Fòrmula: C₁₃H₁₈N₆O₃S₂
Peso molecular:370.45

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

MK175 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
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Bioz

Actividad biológica

Descripciòn

IC₅₀ & Target^[1]

IL-1β

Ver todos los productos específicos de isoformas Interleukin Related :

In Vitro

MK175 (30 μg/mL; 24 h) effectively inhibits LPS (HY-D1056)-induced IL-1β release from human aortic smooth muscle cells (HAoSMCs)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Peso molecular 370.45
Fòrmula C₁₃H₁₈N₆O₃S₂
SMILES

O=C(N1CCN(C2=C3N=CNC3=NC=N2)CC1)CCSS(=O)(C)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Pournara DT, et al. Design and Synthesis of Novel Purine Analogues as Potential IL-1β Inhibitors Targeting Vascular Inflammation. Chem Biodivers. 2026;23(1):e02588. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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- In Vitro
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MK175

Ver todos los productos específicos de isoformas Interleukin Related

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

MK175 Related Classifications

HY-181121 Related Classifications