ORF 17583
ORF 17583 is a Ranitidine (HY-B0693) analogue and H2 receptor antagonist. ORF 17583 exhibits typical reversible competitive antagonism in the guinea pig right atria model, causing a dose-dependent rightward shift of the histamine concentration-response curve without reducing the maximum effect, and its action is fully reversible upon washing. ORF 17583 can be used for research on peptic ulcers and hyperacidity.
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- No. CAS: 78441-46-0
- Fòrmula: C13H21N5O2S2
- Peso molecular:343.47
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
ORF 17583 (100-1000 nM; 30 min) exhibits typical reversible competitive antagonism in the guinea pig right atria model, causing a dose-dependent rightward shift of the histamine concentration-response curve without reducing the maximum effect, and its action is fully reversible upon washing[1].
ORF 17583 (1-10 μM; 60 min) significantly inhibits histamine-induced gastric acid secretion at a concentration of 10 µM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 78441-46-0
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Peso molecular 343.47
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Fòrmula C13H21N5O2S2
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SMILES
O=S1N=C(C(NCCSCC2=CC=C(CN(C)C)O2)=N1)NC
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)