PAT-347
Based on 1 Customer Validation
PAT-347 is an inhibitor of autotaxin (ATX, ENPP-2). PAT-347 binds only to the hydrophobic channel of ATX, without occupying its hydrophobic pocket and catalytic site. PAT-347 blocks the binding of lysophosphatidylcholine (LPC) to the catalytic site of ATX.
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- Pureza: 98.63%
- No. CAS: 1689554-51-5
- Fòrmula: C28H21ClF2N2O3S
- Peso molecular:538.99
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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- Referencias
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Help & FAQs
Actividad biológica
Descripciòn
IC50 & Target
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Autotaxin |
Chemical Information
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No. CAS 1689554-51-5
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Appearance Solid
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Peso molecular 538.99
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Fòrmula C28H21ClF2N2O3S
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Color White to off-white
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SMILES
O=C(O)C1=CC=CC(SC2=C(C)N(CC(N3CC4(C5=C3C=CC=C5)CC4)=O)C6=C2C=CC(Cl)=C6F)=C1F
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Pureza y Documentación
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Ficha de datos (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Joncour A, et al. Discovery, Structure-Activity Relationship, and Binding Mode of an Imidazo[1,2-a]pyridine Series of Autotaxin Inhibitors. J Med Chem. 2017 Sep 14;60(17):7371-7392. . [Content Brief]
[2]. Chen Y, et al. Design, synthesis and anti-fibrosis evaluation of imidazo[1,2-a]pyridine derivatives as potent ATX inhibitors. Bioorg Med Chem. 2021 Sep 15;46:116362. doi: 10.1016/j.bmc.2021.116362. Epub 2021 Aug 13. PMID: 34428714. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PAT-347 Related Classifications
HY-126233 Related Classifications
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