PF-4479745
PF-4479745 is a potent and selective 5-HT2C receptor agonist (EC50: 10 nM, ki: 15 nM). PF-4479745 can be used in the research of cardiovascular disease like hypertension.
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- No. CAS: 1065110-43-1
- Fòrmula: C17H22N4
- Peso molecular:282.38
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Chemical Information
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Ver todos los productos específicos de isoformas 5-HT Receptor
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Actividad biológica
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5-HT2C Receptor |
5-HT2C Receptor 10 nM (EC50) |
5-HT2C Receptor 15 nM (Ki) |
5-HT2A Receptor 360 nM (IC50) |
5-HT2B Receptor 67 nM (IC50) |
5-HT1A Receptor 500 nM (IC50) |
5-HT6 Receptor 280 nM (IC50) |
PF-4479745 (copmpound 17) exhibits metabolic stability in both human liver microsomes (HLM) and human hepatocytes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
PF-4479745 demonstrates a robust dose-dependent effect in canine PUP (peak urethral pressure) model of SUI (stress urinary incontinence)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 1065110-43-1
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Peso molecular 282.38
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Fòrmula C17H22N4
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SMILES
CNC1=C2C([C@H](CNCC2)C)=NC(CC3=CC=CC=C3)=N1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PF-4479745 Related Classifications
HY-118339 Related Classifications
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