PQ32
PQ32 is an antitumor agent that targets c-MYC Pu27 and KRAS G-quadruplexes. PQ32 inhibits tumor cell proliferation, arrests the cell cycle at the G2 phase, and induces apoptosis. PQ32 inhibits the expression of c-MYC and KRAS genes. PQ32 can inhibit tumor growth in mice and is used in the study of lymphoma, breast cancer, lung cancer, hepatocellular carcinoma, colorectal cancer, and other cancers.
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- Fòrmula: C27H21N3O6
- Peso molecular:483.47
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
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K-RAS |
PQ32 shows anti-tumor activity against RAJI, CA46, MDA-MB-231, A549, HepG2, HT29, HEK-293T cells, with IC50s of 1.75, 2.68, 1.07, 3.48, 2.72, 1.50, 4.09 μM, respectively[1].
PQ32 (1.5 μM, 24 h) induces cell cycle arrest and apoptosis in MDA-MB-231 cells[1].
PQ32 (1.5-3 μM, 24-72 h) inhibits c-MYC and KRAS gene and protein expression in MDA-MB-231 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-231
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Concentration:1.5 μM
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Incubation Time:24 h
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Result:Arrested the cells in the G2 phase (increasing from 4.01% to 27.01%).
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Cell Line:MDA-MB-231
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Concentration:1.5 μM
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Incubation Time:24 h
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Result:Induced cell apoptosis (46.84%).
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Cell Line:MDA-MB-231
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Concentration:1.5 μM, 3 μM
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Incubation Time:24 h, 48 h, 72 h
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Result:Inhibited c-MYC and KRAS gene expression.
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Cell Line:MDA-MB-231
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Concentration:1.5 μM, 3 μM
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Incubation Time:24 h, 48 h, 72 h
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Result:Inhibited c-MYC and KRAS protein expression.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:HT29 cancer xenografts (5 × 106 cells, s.c.) female nude mice (BALB/c, 4-weeks old, 14-17 g) [1]
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Dosage:15 mg/kg
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Administration:intratumoral injection, every other day, 21 days
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Result:Resulted in a significant reduction in tumor weight with tumor growth inhibition of 59%, displayed time-dependent inhibition of tumor growth.
Chemical Information
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Peso molecular 483.47
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Fòrmula C27H21N3O6
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SMILES
COC(C=CC(CN1C=C2C(C3=CC4=C(C=C3)OCO4)=NN=C2C5=C1C=C6OCOC6=C5)=C7)=C7OC
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PQ32 Related Classifications
HY-175265 Related Classifications
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