Saquayamycin B
Saquayamycin B (compound 3) is a new angucycline antibiotic. Saquayamycin B has antitumor activities against a human lung (H-460) and a human breast cancer cell line (MCF-7) with GI50 values of 12.2 and 15.2 µM respectively .
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- No. CAS: 99260-67-0
- Fòrmula: C43H48O16
- Peso molecular:820.83
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MCF7 | GI50 |
15.2 μM
Compound: 3
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Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
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[PMID: 18666798] |
| MCF7 | GI50 |
15.2 μmol
Compound: 3
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Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
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[PMID: 18666798] |
| NCI-H460 | GI50 |
12.2 μM
Compound: 3
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Cytotoxicity against human H460 cells after 48 hrs by SRB assay
Cytotoxicity against human H460 cells after 48 hrs by SRB assay
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[PMID: 18666798] |
| NCI-H460 | GI50 |
12.2 μmol
Compound: 3
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Cytotoxicity against human H460 cells after 48 hrs by SRB assay
Cytotoxicity against human H460 cells after 48 hrs by SRB assay
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[PMID: 18666798] |
| NCI-H460 | GI50 |
3.929 μM
Compound: 8
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Growth inhibition of human NCI-H460 cells incubated for 48 hrs by resazurin dye reduction based fluorimetric assay
Growth inhibition of human NCI-H460 cells incubated for 48 hrs by resazurin dye reduction based fluorimetric assay
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[PMID: 22758660] |
| PC-3 | GI50 |
0.07454 μM
Compound: 8
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Growth inhibition of human PC3 cells incubated for 48 hrs by resazurin dye reduction based fluorimetric assay
Growth inhibition of human PC3 cells incubated for 48 hrs by resazurin dye reduction based fluorimetric assay
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[PMID: 22758660] |
Chemical Information
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No. CAS 99260-67-0
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Peso molecular 820.83
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Fòrmula C43H48O16
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SMILES
O=C1C[C@@](O[C@H]2CC[C@H](O[C@H]3C=CC([C@H](C)O3)=O)[C@H](C)O2)(C)C[C@]4(O)[C@@]1(O)C(C(C5=CC=C([C@H]6C[C@@]7([H])O[C@](CC([C@H](C)O8)=O)([H])[C@]8([H])O[C@]7([H])[C@@H](C)O6)C(O)=C5C9=O)=O)=C9C=C4
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Structure Classification
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Initial Source
Streptomyces sp.
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Saquayamycin B Related Classifications
HY-126803 Related Classifications
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