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Referencia número: HY-N19136

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SB87-Cl

SB87-Cl is a halogenated benzophenone antibiotic that can be isolated from fungi of the genus Pestalotiopsis. SB87-Cl exhibits strong antibacterial activity against Gram-positive bacteria, but is accompanied by cytotoxicity to mammalian cells. SB87-Cl can be used in studies of Staphylococcus aureus infection, methicillin (Methicillin (HY-121544))-resistant Staphylococcus aureus (MRSA) infection, and vancomycin (Vancomycin (HY-B0671))-susceptible Enterococcus faecium (VSE) infection.

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No. CAS: 163768-83-0
Fòrmula: C₂₀H₁₈Cl₂O₆
Peso molecular:425.26

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Please store the product under the recommended conditions in the Certificate of Analysis.

SB87-Cl Chemical Structure

No. CAS: 163768-83-0

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In Vitro

SB87-Cl (0.31-10 μg/mL; 6-8 h) exhibits antibacterial activity against Staphylococcus aureus (MIC = 2.5 μg/mL), methicillin-resistant Staphylococcus aureus (MIC = 2.5 μg/mL), and vancomycin-sensitive Enterococcus faecium (MIC = 1.25 μg/mL), but shows no inhibitory effect on vancomycin-resistant Enterococcus faecium even at concentrations up to 10 μg/mL^[1].
SB87-Cl (0.016-50 μM) exhibits cytotoxicity against A549, HeLa, HepG2, MCF-7 and Vero cells, with IC₅₀ values of 2.9, 2.1, 3.9, 4.6 and 2.4 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 163768-83-0
Peso molecular 425.26
Fòrmula C₂₀H₁₈Cl₂O₆
SMILES

O=CC1=C(C=C(C(C/C=C(C)\C)=C1C(C2=C(C(Cl)=C(C)C(Cl)=C2O)O)=O)O)O
Structure Classification
- Phenols
- Polyphenols
Initial Source
- Microorganisms
Chrysosporium
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Jiang Z, et al. Pestalotinones A-D, new benzophenone antibiotics from endophytic fungus Pestalotiopsis trachicarpicola SC-J551. The Journal of antibiotics. 2022 Apr;75(4):207-212. [Content Brief]

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SB87-Cl

Ver todos los productos específicos de isoformas Antibiotic