SD-2301
SD-2301 is a selective STAT3 PROTAC degrader. SD-2301 induces STAT3 degradation without affecting the protein levels of other STAT family members (STAT1, STAT2, STAT4, STAT5, STAT6). SD-2301 exerts anti-tumor effects in B16F10-bearing mice. SD-2301 can be used for the study of cancer.
(Pink: STAT3 ligand (HY-172947); Blue: VHL ligand (HY-112078); Black: linker (HY-W577012)).
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- No. CAS: 3054116-24-1
- Fòrmula: C64H80N13O15PS2
- Peso molecular:1366.50
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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STAT3 |
VHL |
SD-2301 (50 nM, 24 h) effectively degrades STAT3 protein in mouse dendritic cells (DCs)[1].
SD-2301 (0.32-200 nM, 14 h) exhibits high potency and selectivity in inducing degradation of STAT3 over other STAT proteins (STAT1, STAT2, STAT4, STAT5, STAT6) in human peripheral blood mononuclear cells (PBMCs)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
SD-2301 (5 mg/kg, i.v., once every 3 days) increases the proportion of KSPWFTTL tetramer+CD8+ T cells in tumor-infiltrating lymphocytes of MC38-bearing C57BL/6J mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:B16F10 cells (2 × 105) were subcutaneously implanted into the flanks of 6-8-week-old C57BL/6J mice[1]
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Dosage:5 mg/kg
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Administration:i.v., once every 3 days, 4 weeks
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Result:Exhibited potency in inhibiting tumor growth.
Increased the number of effector CD8+ T cells (IFNγ+, GZMB+) in tumors.
Showed no significant changes in body weight.
Degraded STAT3 protein.
Chemical Information
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No. CAS 3054116-24-1
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Peso molecular 1366.50
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Fòrmula C64H80N13O15PS2
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SMILES
O=C([C@@H](NC([C@@H]1CC[C@@H]2CCN(C[C@@H](C(N12)=O)NC(C3=CC4=C(N3)C=CC(C(P(O)(O)=O)=O)=C4)=O)C(CCCCC5=CN(N=N5)[C@@H](C(C)(C)C)C(N6C[C@@H](C[C@H]6C(N[C@H](C7=CC=C(C=C7)C8=C(N=CS8)C)C)=O)O)=O)=O)=O)CCC(N)=O)NCC(C=C9)=CC=C9S(=O)(CC)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SD-2301 Related Classifications
HY-172946 Related Classifications
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