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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
73 Results for "
depolymerization
" in MedChemExpress (MCE) Product Catalog:
Products (73)
73 Results for "depolymerization" in MCE Product Catalog:
172
172
172 Publications Verification
Referencia número: HY-B0011A
No. CAS: 148408-66-6
Synonyms: RP-56976 Trihydrate
Target:
Áreas de investigación:
Docetaxel Trihydrate (RP-56976 Trihydrate) is an antineoplastic agent and inhibits microtubule depolymerization with an IC50 value of 0.2 μM . Docetaxel Trihydrate is a semisynthetic analog of taxol and attenuates the effects of bcl-2 and bcl-xL gene expression. Docetaxel Trihydrate arrests the cell cycle at G2/M and leads to cell apoptosis .
100
100 Cited Publications
Referencia número: HY-N6682
No. CAS: 22144-77-0
Synonyms: Zygosporin A; NSC 209835
Target:
19
19 Cited Publications
Referencia número: HY-107910
No. CAS: 37326-33-3
Synonyms: Hyaluronate 4-glycanohydrolase, Bovine testes; Hyaluronoglucosaminidase, Bovine testes
Target:
Áreas de investigación:
Hyaluronidase, Bovine testes (Hyaluronate 4-glycanohydrolase; Hyaluronoglucosaminidase) is an endoglycosidase that depolymerizes Hyaluronic acid (HA) (HY-B0633A) by cleavage of glycosidic bonds. Hyaluronidase degrades HA and activates membrane receptors that trigger pathways converging in NF-κB activation. Hyaluronidase is employed in the research of granulomatous foreign body reactions, soft-tissue necrosis caused by vascular compromise and uncomplicated nodules, overcorrection, inflamed nodules or tissue ischemia associated with HA filler injection .
4
Category:
Terpenoids Taxaceae Diterpenoids Plants Disease Research Fields Cancer Taxus chinensis (Pilger) Rehd.
Target:
3
3 Cited Publications
Synonyms: NPI-2358
Target:
Áreas de investigación:
Plinabulin (NPI-2358) is a vascular disrupting agen (VDA) against tubulin-depolymerizing with an IC50 of 9.8 nM against HT-29 cells . Plinabulin binds the colchicine binding site of β-tubulin preventing polymerization and has potent inhibitory to tumor cells .
2
2 Cited Publications
Referencia número: HY-N2438
No. CAS: 74805-91-7
Category:
Ophiopogon japonicus (L. f.) Ker-Gawl. Liliaceae Flavonoids Other Diseases Phenols Polyphenols Plants Disease Research Fields Other Flavonoids
Target:
1
Target:
Áreas de investigación:
Estramustine, an estradiol analog, is an orally active antimicrotubule chemotherapy agent. Estramustine depolymerises microtubules by binding to microtubule associated proteins (MAPs) and/or to tubulin. Estramustine can interfere mitosis, trigger cell death and induce apoptosis, which can be used for the research of cancer like prostate cancer .
1
1 Cited Publications
Synonyms: DHNQ; 5,8-Dihydroxy-1,4-naphthoquinone
1
1 Cited Publications
Target:
Áreas de investigación:
Combretastatin A-1 is a microtubule polymerization inhibitor that binds to the colchicine-binding site of tubulin. Combretastatin A-1 inhibits the Wnt/β-catenin pathway through tubulin depolymerization mediated AKT deactivation. Combretastatin A-1 exhibits anti-tumor and anti-vascular effects .
1
1 Cited Publications
Target:
Áreas de investigación:
S-Me-DM4 is a metabolite of DM4 S-methylated by intracellular enzyme. DM4 (HY-100503) is a microtubule-depolymerizing maytansinoid with strong cytotoxicity. DM4 can be used as an ADC Cytotoxin molecule .
1
1 Cited Publications
Referencia número: HY-N1391
No. CAS: 78432-77-6
Synonyms: 10-Deacetylpaclitaxel
Category:
Terpenoids Taxaceae Diterpenoids Plants Disease Research Fields Cancer Taxus wallichiana Zucc.
Target:
1
1 Cited Publications
Referencia número: HY-16191
No. CAS: 1233948-35-0
Áreas de investigación:
ELR510444 is an orally active tubulin inhibitor with an IC50 of 10 μM. ELR510444 binds to the colchicine-binding site on β-tubulin, inhibits tubulin assembly, depolymerizes microtubules and blocks HIF activity. ELR510444 induces cellular microtubule loss, abnormal mitotic spindle, mitotic arrest, apoptosis, morphological changes in tumor endothelial cells, and inhibits cancer cell proliferation, angiogenesis and tumor growth. ELR510444 can be used in research related to various cancers such as renal cell carcinoma .
Referencia número: HY-W002112
No. CAS: 5746-86-1
Synonyms: Nornicotine
Target:
Referencia número: HY-P2031
No. CAS: 26645-35-2
Target:
Referencia número: HY-N1408
No. CAS: 22255-22-7
Synonyms: trans-trismethoxy Resveratrol; (E)-Resveratrol trimethyl ether; trans-3,5,4'-Trimethoxystilbene
Referencia número: HY-132188
No. CAS: 114995-15-2
Referencia número: HY-B0011S
No. CAS: 940867-25-4
Synonyms: RP-56976-d9
Áreas de investigación:
UMK57 is a MCAK activator and kinetochore-microtubule destabilizer. UMK57 enhances MCAK-dependent microtubule depolymerization, increases kinetochore-microtubule turnover, reduces chromosome mis-segregation and lagging chromosomes, and inhibits cancer cell proliferation. UMK57 triggers adaptive resistance in Aurora B cancer cells via reversible Aurora B signaling pathway alterations. UMK57 can be used for the research of solid tumors .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
