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Referencia número: HY-125677

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SHetA2

Name: SHetA2
Brand: MedChemExpress
SKU: HY-125677
Price: 81.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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SHetA2 is a derivative of heteroarotinoid, that exhibits cytotoxicity in cancer cells with IC₅₀ of 0.37–4.6 μM. SHetA2 regulates cancer cells differentiation, induces apoptosis through the intrinsic mitochondrial pathway, and arrest cell cycle at G2 phase. SHetA2 exhibits good pharmacokinetic characteristics and antitumor efficacy in mice. SHetA2 is orally active.

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Pureza : 99.7%
No. CAS: 361483-66-1
Fòrmula: C₂₀H₂₃N₃O₂S₂
Peso molecular:401.55

Almacenamiento:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

SHetA2 Chemical Structure

No. CAS: 361483-66-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Cellular Effect
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

Ver todos los productos específicos de isoformas Caspase :

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	2.98 μM Compound: 5, SHetA2	Growth inhibition of human A2780 cells after 72 hrs by MTS dye based cell titer-96 non-rad cell proliferation assay Growth inhibition of human A2780 cells after 72 hrs by MTS dye based cell titer-96 non-rad cell proliferation assay	[PMID: 25880346]
A2780	IC₅₀	3.17 μM Compound: 1; SHetA2, NSC-721689	Antiproliferative activity against human A2780 cells assessed as reduction in cell growth after 72 hrs by CellTiter 96 Non-Rad cell proliferation assay kit method Antiproliferative activity against human A2780 cells assessed as reduction in cell growth after 72 hrs by CellTiter 96 Non-Rad cell proliferation assay kit method	[PMID: 30878829]
A2780	IC₅₀	3.17 μM Compound: NSC 721689, SHetA2; 1	Growth inhibition of human A2780 cells after 72 hrs by CellTiter-96 assay Growth inhibition of human A2780 cells after 72 hrs by CellTiter-96 assay	[PMID: 30245396]
A2780	IC₅₀	3.17 μM Compound: SHetA2; NSC 721689	Antiproliferative activity against human A2780 cells assessed as cell growth inhibition measured after 72 hrs by CellTiter 96 non-radioactive cell proliferation assay Antiproliferative activity against human A2780 cells assessed as cell growth inhibition measured after 72 hrs by CellTiter 96 non-radioactive cell proliferation assay	[PMID: 31831296]
DU-145	GI₅₀	3.47 μM Compound: SHetA2	Cytotoxicity against human DU145 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human DU145 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 25701251]
DU-145	GI₅₀	4.9 μM Compound: SHetA2	Growth inhibition of human DU145 cells Growth inhibition of human DU145 cells	[PMID: 25701251]
LNCaP	GI₅₀	2.25 μM Compound: SHetA2	Cytotoxicity against human LNCAP cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human LNCAP cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 25701251]
MCF7	GI₅₀	4.13 μM Compound: SHetA2	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 25701251]
MCF7	GI₅₀	4.5 μM Compound: SHetA2	Growth inhibition of human MCF7 cells Growth inhibition of human MCF7 cells	[PMID: 25701251]
MDA-MB-453	GI₅₀	3.27 μM Compound: SHetA2	Cytotoxicity against human MDA-MB-453 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human MDA-MB-453 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 25701251]
MDA-MB-453	GI₅₀	5 μM Compound: SHetA2	Growth inhibition of human MDA-MB-453 cells Growth inhibition of human MDA-MB-453 cells	[PMID: 25701251]
PC-3	GI₅₀	4.8 μM Compound: SHetA2	Cytotoxicity against human PC3 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human PC3 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 25701251]
PC-3	GI₅₀	5 μM Compound: SHetA2	Growth inhibition of human PC3 cells Growth inhibition of human PC3 cells	[PMID: 25701251]
T47D	GI₅₀	3.99 μM Compound: SHetA2	Cytotoxicity against human T47D cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human T47D cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 25701251]
T47D	GI₅₀	4.8 μM Compound: SHetA2	Growth inhibition of human T47D cells Growth inhibition of human T47D cells	[PMID: 25701251]

Chemical Information

No. CAS 361483-66-1
Appearance Solid
Peso molecular 401.55
Fòrmula C₂₀H₂₃N₃O₂S₂
Color White to yellow
SMILES

S=C(NC1=CC=C([N+]([O-])=O)C=C1)NC2=CC3=C(SC(C)(CC3(C)C)C)C=C2
Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (266 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Zhang Y, et al., High performance liquid chromatographic analysis and preclinical pharmacokinetics of the heteroarotinoid antitumor agent, SHetA2. Cancer Chemother Pharmacol. 2006 Nov;58(5):561-9. [Content Brief]

[2]. Benbrook DM, et al., Flexible heteroarotinoids (Flex-Hets) exhibit improved therapeutic ratios as anti-cancer agents over retinoic acid receptor agonists. Invest New Drugs. 2005 Oct;23(5):417-28. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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