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Referencia número: HY-150895

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SI-191

SI-191 is a STAT3 inhibitor and a target protein ligand. SI-191 inhibits the growth of cancer cells. SI-191 can be used in the research of acute leukemia and lymphoma. SI-191 can be used for the synthesis of PROTAC SD-91 (HY-150251).

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 2754428-37-8
Fòrmula: C₄₀H₄₄N₇O₁₀P
Peso molecular:813.79

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

SI-191 Chemical Structure

No. CAS: 2754428-37-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Pureza y Documentación
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Bioz

Actividad biológica

Descripciòn

IC₅₀ & Target^[1]

STAT3

Ver todos los productos específicos de isoformas STAT :

Cellular Effect

Cell Line	Type	Value	Description	References
SU-DHL-1	IC₅₀	>10 μM Compound: SI-191	Antiproliferative activity against human SU-DHL-1 cells assessed as cell growth inhibition incubated for 4 days by CellTiter-Glo asssay Antiproliferative activity against human SU-DHL-1 cells assessed as cell growth inhibition incubated for 4 days by CellTiter-Glo asssay	[PMID: 34141084]

In Vitro

SI-191 (>10 μM) inhibits the growth of MOLM-16 acute leukemia cells, SU-DHL-1 lymphoma cells, and SUP-M2 lymphoma cells with IC₅₀ values greater than 10 μM for all three cell lines^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 2754428-37-8
Peso molecular 813.79
Fòrmula C₄₀H₄₄N₇O₁₀P
SMILES

CC(N1CC[C@H]2CC[C@H](N2C([C@H](C1)NC(C3=CC4=CC(C(P(O)(O)=O)=O)=CC=C4N3)=O)=O)C(N[C@H](C(NC(C5=CC=CC=C5)C6=CC=CC=C6)=O)CCC(N)=O)=O)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Zhou H, et al. SD-91 as A Potent and Selective STAT3 Degrader Capable of Achieving Complete and Long-Lasting Tumor Regression. ACS Med Chem Lett. 2021 May 10;12(6):996-1004. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureza y Documentación
Referencias

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SI-191

Ver todos los productos específicos de isoformas STAT

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

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SI-191 Related Classifications

HY-150895 Related Classifications