TD-165
Based on 1 publication(s) in Google Scholar
TD-165 is a PROTAC-based cereblon (CRBN) degrader. TD-165 comprises a cereblon (CRBN) ligand binding group, a linker and an von Hippel-Landau (VHL) binding group.
(Pink: Cereblon ligand (HY-10984); Blue: VHL ligand (HY-120217); Black: linker (HY-W142804)).
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.08%
- No. CAS: 2305936-56-3
- Fòrmula: C46H59N7O8S
- Peso molecular:870.07
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Almacenamiento:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) TD-165
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Actividad biológica
Descripciòn
IC50 & Target
[1]|
Cereblon 20.4 nM (DC50) |
In Vitro
TD-165 (0-100 nM; 24 hours) shows 50% degradation concentration (DC50) and maximum degradation (Dmax) value of 20.4 nM and 99.6%, respectively[1]. TD-165 (0.1-10 μM; 24 hours) leads to a concentration-dependent decrease in the level of CRBN proteins in HEK293T cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 2305936-56-3
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Appearance Solid
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Peso molecular 870.07
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Fòrmula C46H59N7O8S
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Color White to yellow
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SMILES
O=C([C@H]1N(C([C@@H](NC(CCCCCCCCCCNC2=CC=CC(C(N3C(CC4)C(NC4=O)=O)=O)=C2C3=O)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC5=CC=C(C6=C(C)N=CS6)C=C5
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Osteoarthritis Cartilage
The cereblon-AMPK (AMP-activated protein kinase) axis in chondrocytes regulates the pathogenesis of osteoarthritis. [Abstract]2024 Dec;32(12):1579-1590. PMID: 39218203
Solvente y solubilidad
In Vitro:
DMSO : 50 mg/mL (57.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.1493 mL | 5.7467 mL | 11.4933 mL | 28.7333 mL |
| 5 mM | 0.2299 mL | 1.1493 mL | 2.2987 mL | 5.7467 mL | |
| 10 mM | 0.1149 mL | 0.5747 mL | 1.1493 mL | 2.8733 mL | |
| 15 mM | 0.0766 mL | 0.3831 mL | 0.7662 mL | 1.9156 mL | |
| 20 mM | 0.0575 mL | 0.2873 mL | 0.5747 mL | 1.4367 mL | |
| 25 mM | 0.0460 mL | 0.2299 mL | 0.4597 mL | 1.1493 mL | |
| 30 mM | 0.0383 mL | 0.1916 mL | 0.3831 mL | 0.9578 mL | |
| 40 mM | 0.0287 mL | 0.1437 mL | 0.2873 mL | 0.7183 mL | |
| 50 mM | 0.0230 mL | 0.1149 mL | 0.2299 mL | 0.5747 mL |
TD-165 Related Classifications
HY-130714 Related Classifications
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