TPN729
TPN729 is a selective phosphodiesterase type 5 (PDE5) inhibitor with an IC50 value of 2.28 nM. TPN729 affects erectile function and it can be used for the research of erectile dysfunction.
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- No. CAS: 936951-20-1
- Fòrmula: C25H36N6O4S
- Peso molecular:516.66
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
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PDE5 2.28 nM (IC50) |
PDE6 45.2 nM (IC50) |
PDE1 566 nM (IC50) |
PDE4 834 nM (IC50) |
PDE11 6090 nM (IC50) |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Sprague-Dawley rats with corpora cavernosa complete exposure[1]
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Dosage:1.25, 2.5 and 5.0 mg/kg
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Administration:Intraduodenal (i.d.) injection; 1.25, 2.5 and 5.0 mg/kg, once
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Result:Dose-dependently increased the maximum intracavernous pressure (ICP) and ICP/blood pressure (BP).
Chemical Information
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No. CAS 936951-20-1
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Peso molecular 516.66
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Fòrmula C25H36N6O4S
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SMILES
O=S(C1=CC=C(OCCC)C(C(NC2=C3N(C)N=C2CCC)=NC3=O)=C1)(N(C)CCN4CCCC4)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TPN729 Related Classifications
HY-116808 Related Classifications
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