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Referencia número: HY-160414

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TRX-COBI

(Synonyms: (R,R)-TRX-COBI; TRX-cobimetinib)

TRX-COBI ((R,R)-TRX-COBI; Trx-cobimetinib) is a MEK inhibitor targeting TRX fragments based on Fe²⁺. TRX-COBI has antitumor activity.

Para uso exclusivo en investigación. No vendemos a pacientes.

Fòrmula: C₃₈H₄₃F₃IN₃O₇
Peso molecular:837.66

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

TRX-COBI Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica

Descripciòn

TRX-COBI ((R,R)-TRX-COBI; Trx-cobimetinib) is a MEK inhibitor targeting TRX fragments based on Fe²⁺. TRX-COBI has antitumor activity^[1].

Ver todos los productos específicos de isoformas MEK :

Chemical Information

Peso molecular 837.66
Fòrmula C₃₈H₄₃F₃IN₃O₇
SMILES

FC(C=C(C=C1)I)=C1NC(C(F)=C(C=C2)F)=C2C(N3CC([C@H]4N(C(O[C@H]5C[C@]6(OOC7([C@@H](C8)C[C@H]9C[C@@H]8C[C@@H]7C9)O6)CCC5)=O)CCCC4)(O)C3)=O
Synonyms

(R,R)-TRX-COBI; TRX-cobimetinib
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Jiang H, et al. Ferrous iron-activatable drug conjugate achieves potent MAPK blockade in KRAS-driven tumors. J Exp Med. 2022 Apr 4;219(4):e20210739. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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TRX-COBI

Ver todos los productos específicos de isoformas MEK

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

TRX-COBI Related Classifications

HY-160414 Related Classifications