TS-002902
Based on 1 Customer Validation
TS-002902 is a selective small-molecule inhibitor of TUT4 and TUT7 enzymes, with IC50 values of 0.36 nM and 9.6 nM, respectively. TS-002902 induces an antiproliferative effect in FOCAD-deficient cancer cells. TS-002902 is applicable for research on FOCAD-deficient solid tumors (including glioblastoma, non-small cell lung cancer, and pancreatic cancer).
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.29%
- Fòrmula: C28H25Cl2N7O4
- Peso molecular:594.45
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
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Help & FAQs
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Actividad biológica
TS-002902 potently inhibits purified human TUT7 catalytic activity with an IC50 of 9.6 nM[1].
TS-002902 potently inhibits purified human TUT4 catalytic activity with an IC50 of 0.36 nM[1].
TS-002902 potently inhibits miR-191 uridylation in FOCAD-deleted NCI-H838 cells with a TC50 of 1.9 nM[1].
TS-002902 (7 days) potently reduces viability of FOCAD-deleted NCI-H838 cells with a TC50 of 0.52 μM after 7 days of incubation[1].
TS-002902 (7 days) reduces viability of FOCAD-reconstituted NCI-H838 cells with a TC50 of 3.1 μM after 7 days of incubation[1].
TS-002902 (7 days) reduces viability of FOCAD-normal A549 cells with a TC50 of 11.7 μM after 7 days of incubation[1].
TS-002902 (7 days) exerts a significantly greater antiproliferative effect in FOCAD-deleted cancer cell lines than in FOCAD-normal cancer cell lines after 7 days of incubation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:FOCAD-deleted NCI-H838 non-small cell lung cancer cells
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Concentration:Multiple concentrations (dose-response curve)
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Incubation Time:7 days
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Result:Potently reduced cell viability with a TC50 of 0.52 μM.
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Cell Line:FOCAD-reconstituted NCI-H838 non-small cell lung cancer cells
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Concentration:Multiple concentrations (dose-response curve)
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Incubation Time:7 days
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Result:Reduced cell viability with a TC50 of 3.1 μM.
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Cell Line:FOCAD-normal A549 non-small cell lung cancer cells
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Concentration:Multiple concentrations (dose-response curve)
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Incubation Time:7 days
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Result:Reduced cell viability with a TC50 of 11.7 μM.
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Cell Line:Panel of 60 diverse cancer cell lines (stratified by FOCAD copy number status)
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Concentration:Multiple concentrations (dose-response curve)
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Incubation Time:7 days
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Result:Exerted a significantly higher antiproliferative effect in FOCAD-deleted cell lines compared to FOCAD-normal cell lines.
Chemical Information
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Appearance Solid
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Peso molecular 594.45
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Fòrmula C28H25Cl2N7O4
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Color Light yellow to yellow
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SMILES
CN(C1=NC=C(C=C1)N2C=C(C(C3=CC(Cl)=C(C=C32)N4CCC[C@@H]4COC5=C(C6=C(NC=N6)C=N5)Cl)=O)C(O)=O)C
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 100 mg/mL (168.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (8.41 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (279 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6822 mL | 8.4111 mL | 16.8223 mL | 42.0557 mL |
| 5 mM | 0.3364 mL | 1.6822 mL | 3.3645 mL | 8.4111 mL | |
| 10 mM | 0.1682 mL | 0.8411 mL | 1.6822 mL | 4.2056 mL | |
| 15 mM | 0.1121 mL | 0.5607 mL | 1.1215 mL | 2.8037 mL | |
| 20 mM | 0.0841 mL | 0.4206 mL | 0.8411 mL | 2.1028 mL | |
| 25 mM | 0.0673 mL | 0.3364 mL | 0.6729 mL | 1.6822 mL | |
| 30 mM | 0.0561 mL | 0.2804 mL | 0.5607 mL | 1.4019 mL | |
| 40 mM | 0.0421 mL | 0.2103 mL | 0.4206 mL | 1.0514 mL | |
| 50 mM | 0.0336 mL | 0.1682 mL | 0.3364 mL | 0.8411 mL | |
| 60 mM | 0.0280 mL | 0.1402 mL | 0.2804 mL | 0.7009 mL | |
| 80 mM | 0.0210 mL | 0.1051 mL | 0.2103 mL | 0.5257 mL | |
| 100 mM | 0.0168 mL | 0.0841 mL | 0.1682 mL | 0.4206 mL |
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