TSLP modulator-1
Based on 1 Customer Validation
TSLP modulator-1 (Compound 14O) is a potent TSLP signaling modulator. TSLP modulator-1 exhibits potent inhibition of CCL17 and IL-1β mRNA expression. TSLP modulator-1 attenuates the protein levels of IL-6, IL-4 and IL-13. TSLP modulator-1 significantly attenuates calcium influx. TSLP modulator-1 exerts anti-inflammatory effects. TSLP modulator-1 effectively alleviates pruritus and atopic dermatitis-like symptoms.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.61%
- Fòrmula: C20H24ClF3N2O2
- Peso molecular:416.86
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
Descripciòn
IC50 & Target
[1]|
IL-1β |
IL-6 |
IL-4 |
IL-13 |
Chemical Information
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Appearance Solid
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Peso molecular 416.86
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Fòrmula C20H24ClF3N2O2
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Color White to light yellow
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SMILES
O=C(C(NC)CC)NCC1=CC=C(C=C1)OCC2=CC=C(C=C2)C(F)(F)F.Cl
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
In Vitro:
DMSO : 70 mg/mL (167.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3989 mL | 11.9944 mL | 23.9889 mL | 59.9722 mL |
| 5 mM | 0.4798 mL | 2.3989 mL | 4.7978 mL | 11.9944 mL | |
| 10 mM | 0.2399 mL | 1.1994 mL | 2.3989 mL | 5.9972 mL | |
| 15 mM | 0.1599 mL | 0.7996 mL | 1.5993 mL | 3.9981 mL | |
| 20 mM | 0.1199 mL | 0.5997 mL | 1.1994 mL | 2.9986 mL | |
| 25 mM | 0.0960 mL | 0.4798 mL | 0.9596 mL | 2.3989 mL | |
| 30 mM | 0.0800 mL | 0.3998 mL | 0.7996 mL | 1.9991 mL | |
| 40 mM | 0.0600 mL | 0.2999 mL | 0.5997 mL | 1.4993 mL | |
| 50 mM | 0.0480 mL | 0.2399 mL | 0.4798 mL | 1.1994 mL | |
| 60 mM | 0.0400 mL | 0.1999 mL | 0.3998 mL | 0.9995 mL | |
| 80 mM | 0.0300 mL | 0.1499 mL | 0.2999 mL | 0.7497 mL | |
| 100 mM | 0.0240 mL | 0.1199 mL | 0.2399 mL | 0.5997 mL |
TSLP modulator-1 Related Classifications
HY-181006 Related Classifications
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