UCB-9260
Based on 3 publication(s) in Google Scholar
UCB-9260, an orally active compound, inhibits TNF signaling by stabilising an asymmetric form of the trimer. UCB-9260 is selective for TNF over other superfamily members, and binds TNF with a similar Kd of 13 nM.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.36%
- No. CAS: 1515888-53-5
- Fòrmula: C26H25N5O
- Peso molecular:423.51
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
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Publications Citing Use of MedChemExpress (MCE) UCB-9260
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Ver todos los productos específicos de isoformas TNF Receptor
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Actividad biológica
UCB-9260 (0-10 μM)?inhibits NF-κB with a geometric mean IC50?of 202 nM after TNF (10 pM) stimulation in in Hek-293 cells[1].
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UCB-9260?inhibits TNF-dependent cytotoxicity with a geometric mean IC50?of 116 nM and a geometric mean IC50?of 120 nM, using human and mouse TNF, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
? UCB-9260?(10-300?mg/kg; p.o.) dose-dependently inhibits human and mouse TNF-induced neutrophil recruitment to the peritoneal compartment in adult male Balb/c mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Aged 6-8 weeks adult male Balb/c mice ( CAIA model)[1]
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Dosage:150 mg/kg
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Administration:p.o.; twice daily for 7days
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Result:Showed a significant reduction of the clinical score.
Chemical Information
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No. CAS 1515888-53-5
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Appearance Solid
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Peso molecular 423.51
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Fòrmula C26H25N5O
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SMILES
OC(C1=CC=NC=C1)C2=NC3=CC=C(C4=CN(C)N=C4)C=C3N2CC5=CC(C)=CC=C5C
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (3)
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Journal Impact Factor
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Most Recent
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Biochem Pharmacol
Structural and molecular characterization of a small-molecule TNF-α-TNFR1 inhibitor modulating cell death signaling. [Abstract]2026 Apr:246:117727. PMID: 41571205 -
Int J Mol Sci
An Autocrine Regulator Loop Involving Tumor Necrosis Factor and Chemokine (C-C motif) Ligand-2 Is Activated by Transforming Growth Factor-β in Rat Basophilic Leukemia-2H3 Mast Cells. [Abstract]2025 Apr 30;26(9):4263. PMID: 40362499
UCB-9260 purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2025 Apr 30;26(9):4263. [Abstract]
CCL-2 and TNF concentrations were measured by ELISA in conditioned media from RBL-2H3 cells pre-incubated with UCB-9260 (10 μM; 30 min) and then stimulated with TGF-β (100 pM) for up to 24 h. UCB-9260 mainly inhibited the late secretion of CCL-2 and TNF induced by TGF-β.
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J Inflamm Res
Quercetin, a Compound of the Total Flavonoids of Periploca forrestii Schltr., Ameliorates Rheumatoid Arthritis by Targeting TNF-α. [Abstract]2025 Feb 26:18:2879-2898. PMID: 40046683
UCB-9260 purchased from MedChemExpress. Usage Cited in: J Inflamm Res. 2025 Feb 26:18:2879-2898. [Abstract]
Flow cytometry analysis post-quercetin treatment. UCB-9260 (10 μM; 12 h) served as a positive control.
UCB-9260 purchased from MedChemExpress. Usage Cited in: J Inflamm Res. 2025 Feb 26:18:2879-2898. [Abstract]
Apoptosis rates and flow cytometry analysis post-quercetin treatment. UCB-9260 (10 μM; 12 h) served as a positive control.
UCB-9260 purchased from MedChemExpress. Usage Cited in: J Inflamm Res. 2025 Feb 26:18:2879-2898. [Abstract]
Modulation of luciferase expression by quercetin. NlucP-NF-κB-HEK293T cells were treated with quercetin (5-15 μmol/L), or UCB-9260 (10 μmol/L; positive control) at various concentrations, in the presence or absence of TNF-α (20 ng/mL), for 5 hours.
UCB-9260 purchased from MedChemExpress. Usage Cited in: J Inflamm Res. 2025 Feb 26:18:2879-2898. [Abstract]
Effect of quercetin on inflammatory mediators in MH7A cells. Changes in mRNA levels of COX-2, INOS, IL-6, and IL-1β post-treatment. MH7A cells were treated with quercetin at concentrations of 0.5, 1, and 1.5 μmol/L, in the presence or absence of TNF-α (30 ng/mL), for 24 hours. UCB-9260 (0.5 μmol/L) and MTX (0.5 μg/mL) served as positive controls.
Solvente y solubilidad
DMSO : 125 mg/mL (295.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 6.25 mg/mL (14.76 mM); Clear solution
This protocol yields a clear solution of ≥ 6.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (62.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (277 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3612 mL | 11.8061 mL | 23.6122 mL | 59.0305 mL |
| 5 mM | 0.4722 mL | 2.3612 mL | 4.7224 mL | 11.8061 mL | |
| 10 mM | 0.2361 mL | 1.1806 mL | 2.3612 mL | 5.9030 mL | |
| 15 mM | 0.1574 mL | 0.7871 mL | 1.5741 mL | 3.9354 mL | |
| 20 mM | 0.1181 mL | 0.5903 mL | 1.1806 mL | 2.9515 mL | |
| 25 mM | 0.0944 mL | 0.4722 mL | 0.9445 mL | 2.3612 mL | |
| 30 mM | 0.0787 mL | 0.3935 mL | 0.7871 mL | 1.9677 mL | |
| 40 mM | 0.0590 mL | 0.2952 mL | 0.5903 mL | 1.4758 mL | |
| 50 mM | 0.0472 mL | 0.2361 mL | 0.4722 mL | 1.1806 mL | |
| 60 mM | 0.0394 mL | 0.1968 mL | 0.3935 mL | 0.9838 mL | |
| 80 mM | 0.0295 mL | 0.1476 mL | 0.2952 mL | 0.7379 mL | |
| 100 mM | 0.0236 mL | 0.1181 mL | 0.2361 mL | 0.5903 mL |
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