UCM-1306
Based on 1 Customer Validation
UCM-1306 is a potent and orally active human dopamine D1 receptor allosteric modulator (PAM). UCM-1306 increases the endogenous dopamine (DA) maximal effect both in human and mouse D1 receptors. UCM-1306 is not only for improving motor symptoms but also for addressing the key comorbid cognitive impairment associated with long-term Parkinson’s disease (PD).
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.49%
- No. CAS: 2258608-78-3
- Fòrmula: C14H14FNO2S
- Peso molecular:279.33
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
UCM-1306 (2-(Fluoromethoxy)-4'-(S-methylsulfonimidoyl)-1,1'-biphenyl; 1-10 μM) increases cAMP in a concentration-response manner with high potency (EC50=60 nM).
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
UCM-1306 (1 mg/kg; ip) enhances cocaine-induced hyperlocomotion in adult mice[1].
UCM-1306 (1 mg/kg; ip) helps consolidate long-term memory formation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Adult C57BL/6J mice with cocaine-induced hyperactivity model[1]
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Dosage:1 mg/kg; cocaine (20 mg/kg, sc)
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Administration:Intraperitoneal injection
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Result:Increased cocaine-induced hyperlocomotion, suggesting an in vivo potentiation of DA action at the D1R.
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Animal Model:Adult C57BL/6J mice
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Dosage:1 mg/kg
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Administration:Intraperitoneal injection
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Result:Increased memory trace in C57BL/6J mice.
Chemical Information
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No. CAS 2258608-78-3
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Appearance Solid
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Peso molecular 279.33
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Fòrmula C14H14FNO2S
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Color White to off-white
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SMILES
O=S(C1=CC=C(C2=C(OCF)C=CC=C2)C=C1)(C)=N
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 50 mg/mL (179.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (8.95 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (277 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 3.5800 mL | 17.9000 mL | 35.8000 mL | 89.4999 mL |
| 5 mM | 0.7160 mL | 3.5800 mL | 7.1600 mL | 17.9000 mL | |
| 10 mM | 0.3580 mL | 1.7900 mL | 3.5800 mL | 8.9500 mL | |
| 15 mM | 0.2387 mL | 1.1933 mL | 2.3867 mL | 5.9667 mL | |
| 20 mM | 0.1790 mL | 0.8950 mL | 1.7900 mL | 4.4750 mL | |
| 25 mM | 0.1432 mL | 0.7160 mL | 1.4320 mL | 3.5800 mL | |
| 30 mM | 0.1193 mL | 0.5967 mL | 1.1933 mL | 2.9833 mL | |
| 40 mM | 0.0895 mL | 0.4475 mL | 0.8950 mL | 2.2375 mL | |
| 50 mM | 0.0716 mL | 0.3580 mL | 0.7160 mL | 1.7900 mL | |
| 60 mM | 0.0597 mL | 0.2983 mL | 0.5967 mL | 1.4917 mL | |
| 80 mM | 0.0447 mL | 0.2237 mL | 0.4475 mL | 1.1187 mL | |
| 100 mM | 0.0358 mL | 0.1790 mL | 0.3580 mL | 0.8950 mL |
UCM-1306 Related Classifications
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