UNC10062
UNC10062 is a dopamine D1 receptor (D1R) positive allosteric modulator. UNC10062 specifically binds to the extracellular allosteric pocket (upper pocket) at the interface of transmembrane helices (TM) 1 and 7 of D1R. UNC10062 can increase dopamine potency and D1R-mediated cAMP production. UNC10062 can be used for the research of neurological disease, such as Parkinson's disease.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Fòrmula: C20H23N3O4S
- Peso molecular:401.48
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Ver todos los productos específicos de isoformas Dopamine Receptor
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Actividad biológica
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D1 Receptor |
UNC10062 (50 μM, 90 mins) increases dopamine potency in CHO-K1 cells stably expressing D1R, with an E C50 fold-shift of 3.9[1].
UNC10062 (25-50 μM, 5 mins) synergistically enhances D1R-mediated cAMP production in HEK293 cells when combined with LY3154207 (HY-128770) and BMS-A1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Peso molecular 401.48
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Fòrmula C20H23N3O4S
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SMILES
CC(C)(C1CCC2=C(SC(NC(C3=CC=NC=C3)=O)=C2C(N)=O)C1)C(OC)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
UNC10062 Related Classifications
HY-179241 Related Classifications
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