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Referencia número: HY-158046

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UNC8899

UNC8899 is a STING PROTAC degrader with a DC₅₀ of 1.097 μM. UNC8899 recruits the VHL E3 ligase to mediate the ubiquitination of phosphorylated STING and subsequent proteasomal degradation. UNC8899 can be used in studies of renal cell carcinoma.
(Pink: STING ligand (HY-184545); Blue: VHL ligand (HY-138678B); Black: linker).

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 3094059-37-4
Fòrmula: C₇₁H₉₁N₁₇O₁₃S
Peso molecular:1422.65

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

UNC8899 Chemical Structure

No. CAS: 3094059-37-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Actividad biológica

Descripciòn

UNC8899 is a STING PROTAC degrader with a DC₅₀ of 1.097 μM. UNC8899 recruits the VHL E3 ligase to mediate the ubiquitination of phosphorylated STING and subsequent proteasomal degradation. UNC8899 can be used in studies of renal cell carcinoma^[1]. (Pink: STING ligand (HY-184545); Blue: VHL ligand (HY-138678B); Black: linker).

IC₅₀ & Target

^[1]

VHL

Ver todos los productos específicos de isoformas PROTACs :

In Vitro

UNC8899 (0-31.6 μM；24 h) degrades STING in Caki-1 cells, with a DC50 of 1.097 μM and a Dmax of 99.94%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

Western Blot Analysis^[1]

View Protocol

Cell Line:

Caki-1
Concentration:

0.01, 0.0316, 0.1, 0.316, 1, 3.16, 10, 31.6 μM
Incubation Time:

24 h
Result:

Degraded STING in Caki-1 cells, with a DC₅₀ of 1.097 μM and a D_max of 99.94%.

Chemical Information

No. CAS 3094059-37-4
Peso molecular 1422.65
Fòrmula C₇₁H₉₁N₁₇O₁₃S
SMILES

O=C(NCCOCCOCCC(N[C@@H](C(N1[C@H](C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@H](C1)O)=O)C(C)(C)C)=O)C4=CC5=C(C(OC)=C4)N(C/C=C/CN6C(NC(C7=CC(C)=NN7CC)=O)=NC8=C6C(OCCCN9CCOCC9)=CC(C(N)=O)=C8)C(NC(C%10=CC(C)=NN%10CC)=O)=N5
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Zhu Z, et al. Development of VHL-recruiting STING PROTACs that suppress innate immunity. Cellular and molecular life sciences : CMLS. 2023 May 14;80(6):149. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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UNC8899

Ver todos los productos específicos de isoformas PROTACs

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