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Referencia número: HY-150802

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VH101

VH101 is a VHL E3 ligase-recruiting ligand that can be used to generate PROTACs, such as XL01126 (HY-148030).

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 2135318-53-3
Fòrmula: C₂₆H₃₃FN₄O₄S
Peso molecular:516.63

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

VH101 Chemical Structure

No. CAS: 2135318-53-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Descripciòn

VH101 is a VHL E3 ligase-recruiting ligand that can be used to generate PROTACs, such as XL01126 (HY-148030)^[1].

IC₅₀ & Target^[1]

VHL

Ver todos los productos específicos de isoformas Ligands for E3 Ligase :

In Vitro

VH101 (100 μM; 4.5 h) pretreatment of LRRK2^G2019S MEFs blocks XL01126-induced LRRK2 degradation, confirming VHL-dependent activity of the PROTAC^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 2135318-53-3
Peso molecular 516.63
Fòrmula C₂₆H₃₃FN₄O₄S
SMILES

O=C([C@H]1N(C([C@@H](NC(C2(F)CC2)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC3=CC=C(C4=C(C)N=CS4)C=C3
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Liu X, et al. Discovery of XL01126: A Potent, Fast, Cooperative, Selective, Orally Bioavailable, and Blood-Brain Barrier Penetrant PROTAC Degrader of Leucine-Rich Repeat Kinase 2. Journal of the American Chemical Society. 2022 Sep 21;144(37):16930-16952. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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VH101

Ver todos los productos específicos de isoformas Ligands for E3 Ligase

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

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VH101 Related Classifications

HY-150802 Related Classifications