Referencia número: HY-134957

VT107

Name: VT107
Brand: MedChemExpress
SKU: HY-134957
Price: 130.00 USD
Availability: InStock
Rating: 5 (12 reviews)

12 Cited Publications

Revisión del cliente

Based on 12 publication(s) in Google Scholar

VT-107, as an analogous to VT104, is an orally active and potent pan-TEAD auto-palmitoylation inhibitor. VT-107 can be used for the research of cancer.

Para uso exclusivo en investigación. No vendemos a pacientes.

Pureza : 99.89%
No. CAS: 2417718-63-7
Fòrmula: C₂₅H₂₀F₃N₃O
Peso molecular:435.44

Almacenamiento:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 1 year , -20°C, 6 months

VT107 Chemical Structure

No. CAS: 2417718-63-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (12)
Solvente y solubilidad
- In Vitro
- In Vivo
Pureza y Documentación
Referencias
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

VT-107, as an analogous to VT104, is an orally active and potent pan-TEAD auto-palmitoylation inhibitor. VT-107 can be used for the research of cancer^[1].

IC₅₀ & Target

TEAD^[1]

Ver todos los productos específicos de isoformas YAP :

Cellular Effect

Cell Line	Type	Value	Description	References
NCI-H226	IC₅₀	0.02 μM Compound: VT-107	Cytotoxicity against human NCI-H226 cells assessed as cell viability at 10 uM measured for 7 days by celltiter-glo assay Cytotoxicity against human NCI-H226 cells assessed as cell viability at 10 uM measured for 7 days by celltiter-glo assay	[PMID: 35763499]
NCI-H226	IC₅₀	0.03 μM Compound: 6; VT107	Antiproliferative activity against human NCI-H226 cells incubated for 120 hrs by Celltiter-glo luminescent assay Antiproliferative activity against human NCI-H226 cells incubated for 120 hrs by Celltiter-glo luminescent assay	[PMID: 38746898]

In Vitro

VT107 (3 μmol/L; 20 hours; HEK293T cells) inhibits palmitoylation of both endogenous TEAD1 and TEAD3 proteins and is the most potent at blocking the palmitoylation of endogenous TEAD4 protein^[1].
VT107 prevents palmitoylation of the TEAD1 protein. VT107 is slightly more potent than VT104 on TEAD2 and TEAD4. VT107 results in the disappearance of palmitoylated TEAD1 with a concomitant increase in unpalmitoylated TEAD1. VT107 decreases the levels of palmitoylated TEAD3 and TEAD4 and increases the levels of unpalmitoylated TEAD3 and TEAD4. VT107 blocks YAP and TAZ interaction with both TEAD1 and TEAD4. VT107 potently inhibits the proliferation of NF2-mutated/deficient cell lines^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

HEK293T cells
Concentration:

3 μmol/L
Incubation Time:

20 hours
Result:

Inhibited palmitoylation of both endogenous TEAD1 and TEAD3 proteins and was the most potent at blocking the palmitoylation of endogenous TEAD4 protein.

In Vivo

VT107 (10 mg/kg; p.o.) is a enantiomer analogous to VT104^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Mouse^[1]
Dosage:

10 mg/kg (Pharmacokinetic Analysis)
Administration:

P.o.
Result:

Enantiomer analogous to VT104.

Chemical Information

No. CAS 2417718-63-7
Appearance Solid
Peso molecular 435.44
Fòrmula C₂₅H₂₀F₃N₃O
Color White to off-white
SMILES

O=C(C1=CC=C2C(C3=CC=C(C(F)(F)F)C=C3)=CC=CC2=C1)N[C@H](C4=NC(N)=CC=C4)C
Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	1 year
	-20°C	6 months

Publications (12)

All IF

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Journal Impact Factor

Cell Chem Biol

Enhancer reprogramming underlies therapeutic utility of a SMARCA2 degrader in SMARCA4 mutant cancer. [Abstract]

2024 Dec 19;31(12):2069-2084.e9. PMID: 39378885
J Med Chem

Optimization of TEAD P-Site Binding Fragment Hit into In Vivo Active Lead MSC-4106. [Abstract]

2022 Jul 14;65(13):9206-9229. PMID: 35763499
Acta Neuropathol Commun

Hydrogen peroxide induced by nerve injury promotes axon regeneration via connective tissue growth factor. [Abstract]

2022 Dec 25;10(1):189. PMID: 36567321

VT107 purchased from MedChemExpress. Usage Cited in: Acta Neuropathol Commun. 2022 Dec 25;10(1):189. [Abstract]

VT107 (50 µM) dampens the H2O2-mediated increase in Ctgf levels (Fig. C, D). YAP is in green, Ctgf in red and nuclei are in blue.
Life Sci Alliance

Pipeline to evaluate YAP-TEAD inhibitors indicates TEAD inhibition represses NF2-mutant mesothelioma. [Abstract]

2025 Jul 31;8(10):e202503241. PMID: 40744733
University of Michigan

2026.
bioRxiv

2026 Jul 8.
Res Sq

2026 Jun 17.
bioRxiv

Under Pressure: A unique mechanoresponsive mechanism of body site-specific keratin regulation in palmoplantar epidermis. [Abstract]

2025 Sep 17:2025.09.15.676359. PMID: 41000774
bioRxiv

2025 Aug 10.
bioRxiv

EHE cell cultures: a platform for mechanistic and therapeutic investigation. [Abstract]

2025 Mar 27:2025.03.24.644191. PMID: 40196670
bioRxiv

2024 November 17.
bioRxiv

2024 November 12.

Solvente y solubilidad

In Vitro:

DMSO : 100 mg/mL (229.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.2965 mL

11.4826 mL

22.9653 mL

5 mM

0.4593 mL

2.2965 mL

4.5931 mL

10 mM

0.2297 mL

1.1483 mL

2.2965 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (5.74 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (5.74 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (5.74 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (276 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Tang TT, et al. Small Molecule Inhibitors of TEAD Auto-palmitoylation Selectively Inhibit Proliferation and Tumor Growth of NF2-deficient Mesothelioma. Mol Cancer Ther. 2021; 20(6):986-998. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.2965 mL	11.4826 mL	22.9653 mL	57.4132 mL
	5 mM	0.4593 mL	2.2965 mL	4.5931 mL	11.4826 mL
	10 mM	0.2297 mL	1.1483 mL	2.2965 mL	5.7413 mL
	15 mM	0.1531 mL	0.7655 mL	1.5310 mL	3.8275 mL
	20 mM	0.1148 mL	0.5741 mL	1.1483 mL	2.8707 mL
	25 mM	0.0919 mL	0.4593 mL	0.9186 mL	2.2965 mL
	30 mM	0.0766 mL	0.3828 mL	0.7655 mL	1.9138 mL
	40 mM	0.0574 mL	0.2871 mL	0.5741 mL	1.4353 mL
	50 mM	0.0459 mL	0.2297 mL	0.4593 mL	1.1483 mL
	60 mM	0.0383 mL	0.1914 mL	0.3828 mL	0.9569 mL
	80 mM	0.0287 mL	0.1435 mL	0.2871 mL	0.7177 mL
	100 mM	0.0230 mL	0.1148 mL	0.2297 mL	0.5741 mL

Bioz

Keywords

VT107

12 Cited Publications

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VT107

Publications Citing Use of MedChemExpress (MCE) VT107

Ver todos los productos específicos de isoformas YAP