VU6024578
VU6024578 (BI02982816) is a selective, orally active positive allosteric modulator (PAM) for metabotropic glutamate receptor (mGluR1), that activates human mGluR1 and rat mGluR1 with EC50 of 54 nM and 46 nM. VU6024578 exhibits antipsychotic activity in rats amphetamine-induced hyperactivity models and MK-801 (HY-15084B)-induced novel object recognition (NOR) models. VU6024578 is blood brain barrier penetrable.
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- No. CAS: 3100913-05-8
- Fòrmula: C20H18ClN5O2
- Peso molecular:395.84
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Help & FAQs
Actividad biológica
Descripciòn
IC50 & Target
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rat mGluR1 46 nM (EC50) |
Human mGluR1 54 nM (EC50) |
Chemical Information
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No. CAS 3100913-05-8
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Peso molecular 395.84
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Fòrmula C20H18ClN5O2
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SMILES
O=C(C1=CC(C2=CC=CO2)=CC=C1Cl)NCC3=CC(C4=CC=NN4C)=NN3C
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Synonyms
BI02982816
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
VU6024578 Related Classifications
HY-170499 Related Classifications
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