VU6032735
Based on 1 Customer Validation
VU6032735 is a potent and subtype-selective sperm-specific potassium channel 3 (SLO3) inhibitor with IC50 values of 165 nM (hSLO3) and 730 nM (mSLO3). VU6032735 also inhibits sodium channel and L-type calcium channel VU6032735 can sustain high tissue exposure in the fertilized oviduct. VU6032735 can be used for the research of contraception.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.26%
- Fòrmula: C25H21F6N3O3
- Peso molecular:525.44
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Almacenamiento:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Chemical Information
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Ver todos los productos específicos de isoformas Calcium Channel
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Actividad biológica
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hSLO3 165 nM (IC50) |
mSLO3 730 nM (IC50) |
L-type calcium channel |
VU6032735 (10 μM, 1-2 h) significantly inhibits human sperm hyperactivated motility[1].
VU6032735 (0.01-1 μM) inhibits mouse SLO3-γ2 channels in HEK293 cells[1].
VU6032735 (10 μM) inhibits sodium channel and L-type calcium channel[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Peso molecular 525.44
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Fòrmula C25H21F6N3O3
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Color White to off-white
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SMILES
O=C(C1=CC=C(OCC2=CC=C(OC(F)(F)F)C=C2)C=C1)N3CCN(C4=NC=C(C(F)(F)F)C=C4)CC3
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Pureza y Documentación
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Ficha de datos (265 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
VU6032735 Related Classifications
HY-175728 Related Classifications
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